DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt5b4

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001074161.1	Gene:	ugt5b4 / 791210	ZFINID:	ZDB-GENE-070112-2332	Length:	531	Species:	Danio rerio

Alignment Length:	537	Identity:	159/537 - (29%)
Similarity:	266/537 - (49%)	Gaps:	69/537 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VCLLGTGDGARILAP-------FFLPVK-SHFMMTDAIIRELVKRGHEVTFITPL-SLAKENLGP 65
            :|||      .::||       ...||. ||::..:.::..|..:||.:|.|... |...:...|
Zfish    14 LCLL------LVMAPVVESGNVLVFPVDGSHWVNMNILVEALHAKGHNITVIRMSDSWYIKEFSP 72

  Fly    66 NYREILLPK--------YDTWA--------DISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTD 114
            :|..|.|..        .:|:|        |.|...:.|..::|. .|.|..|...:.:.|...
Zfish    73 HYTSITLKSSGGFSEDILETFASRLITILRDGSTWGRLKLEMEMW-QSSLKIMETEREMIINMI- 135

  Fly   115 FALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFG--- 176
                  |.|:||.:. ||.|:||.|.:. ...|.::||...::|.:....:|       :||
Zfish   136 ------EDQQLIDSL-KKTKYDLFLTDP-AMYGGVILGNYLKLPIVYNVRWA-------IFGEGH 185

  Fly   177 FV---NPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRV- 237
            ||   :||||||...|...||||..||::|||:.    ::.|.    |...:|...::.|..|.
Zfish   186 FVIAPSPLSYVPVAMLELPDRMSFLERVKNVVMY----IITET----QIAFLIAPTYNVLCERFI 242

  Fly   238 -PTVK--QLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA-EHGAI 298
             |.|.  .|.|...:.|..:......|||...|::.:.|....|.||||:.:::::.:: :||.|
Zfish   243 GPGVNLFNLVQGADLWLHRADFVFEYPRPTMPNIVYMAGFQCKPSKPLPKDLEDFVQSSGDHGVI 307

  Fly   299 YFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNV 363
            ..|||:.:  ..:|.:..:...:.||.|.|:::|:::..:...|.:|..:..|:||.|:|.||..
Zfish   308 VMSLGTII--GQLPDDVAEAIAEAFAELPQKIIWRYKGKRPSALGNNTLIMDWMPQNDLLGHPKT 370

  Fly   364 KVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALL 428
            :.|:||||..|:|||:||.||::|....|||..|:...:..|.|..:|:.|:.|:.....:..:|
Zfish   371 RAFVAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMDKESFLKTVKEVL 435

  Fly   429 KDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIIL 493
            .||.|:.||.:.||:.:|.|:..:|.|::||.:|:.|:||.||......:|||.::.:||..:::
Zfish   436 YDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVILVLI 500

  Fly   494 AITLLPLLTLYAVSRNY 510
            :...|.:|::|||.|.:
Zfish   501 SAVSLIILSIYAVIRYF 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	154/527 (29%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	146/493 (30%)
ugt5b4	NP_001074161.1	egt	12..501	CDD:223071	153/519 (29%)
ugt5b4	NP_001074161.1	UDPGT	27..531	CDD:278624	154/518 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585207
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790