DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt5a2

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001070191.2	Gene:	ugt5a2 / 767756	ZFINID:	ZDB-GENE-061103-373	Length:	524	Species:	Danio rerio

Alignment Length:	538	Identity:	150/538 - (27%)
Similarity:	258/538 - (47%)	Gaps:	78/538 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFI-----------TPL--SL 58
            |.:|:|......::|.   :||: ||::....:|.||..|||.:|.:           :||  |:
Zfish    11 LLLCVLSRSYAGKLLV---VPVEGSHWVNMKVLIVELHSRGHSITVVRGSSSWYIEEQSPLYTSI 72

  Fly    59 AKEN--LGPNYREILLPKY--------DTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKST 113
            ..:|  ...::.|..||..        ..|.:::.      |.:||.....||.:......|...
Zfish    73 TVDNGVFDDDFMEKFLPHLLKIQRQGKSFWNEMAL------ADEMIHFVTETHKQSCNMTAILFE 131

  Fly   114 DFALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALM-----LGYIYEIPAITIATFAYANYFSQ 173
            :         |.:....|...:|::|.:..:..|.|:     |..:|.:        .:..|...
Zfish   132 N---------ETLMNSLKDAAYDVVLTDPAYGSGVLLAHRLGLPLVYNV--------RWTVYGEA 179

  Fly   174 VFGFV-NPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSY-----YPQQDAVIRKHFSS 232
            .|... :||||||...|..||:|:..:|:.|::..    ::....|     .|.|: :.:|:|.
Zfish   180 HFDIAPSPLSYVPVSGLQLTDKMTFSQRVMNMMTY----IMIRYKYSKNFGSPYQE-LTQKYFG- 238

  Fly   233 LLPRVPTVK--QLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA-E 294
                 |.|.  .|.|:..:.|:.:......|||...|::.:||....|.||||..::.::.:: |
Zfish   239 -----PNVNFFSLLQDADLWLMRNDFTFEFPRPTMPNVVYMGGFQCKPAKPLPGDLEEFVQSSGE 298

  Fly   295 HGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILA 359
            ||.|..|||:..  ..:.:|........||.|.|:|:|::...:..||.:|..:..||||.|:|.
Zfish   299 HGVIMMSLGTVF--GQLLSELNDEIAAAFAQLPQKVIWRYTGPRPANLGNNTLIVNWLPQNDLLG 361

  Fly   360 HPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSAL 424
            ||..|:|:||||..|:|||:||.||::|:|..|||..|:...:|.|.|..:::.|:.:.....||
Zfish   362 HPKTKLFVAHGGTNGLQEAIYHGVPIVGLPLAFDQPDNLSRMRAKGTAKIVEFATLDRAVFLEAL 426

  Fly   425 HALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDV- 488
            ..:|.:|.|:.||.:.|::..|:|:..:|.|::||.:|:.::|||||.|....:.|.::..:||
Zfish   427 KEVLHNPSYRENMQRLSKLHHDQPMKPLDRAIFWIEFVMRNKGAPHLRAQSFRMSWIEYQSIDVI 491

  Fly   489 SAIILAITLLPLLTLYAV 506
            ..::|.:.:..|||:|.:
Zfish   492 LTLMLMVLVFVLLTVYTM 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	147/532 (28%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	140/503 (28%)
ugt5a2	NP_001070191.2	UDPGT	22..524	CDD:278624	147/527 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585198
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.790