DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt2a5

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001070111.2	Gene:	ugt2a5 / 767705	ZFINID:	ZDB-GENE-060929-796	Length:	532	Species:	Danio rerio

Alignment Length:	553	Identity:	164/553 - (29%)
Similarity:	276/553 - (49%)	Gaps:	65/553 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFVCLL----GTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFITPLS------LAKE 61
            |.||||    ..|...|:|.   :|.: ||:.....:|..||.:.|.||.:...|      ..||
Zfish     6 LLVCLLLCGVDVGWSGRVLV---MPGEYSHWHNMRPVIEALVDKNHSVTVLVGSSSPTVPHTQKE 67

  Fly    62 NLGPNYREILLPKYDTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDFAL-----AHPE 121
            ....:..::.:.|.:  ||  |.|:     |||.:  .|:...|::.|    :|.:     ...|
Zfish    68 RFEYHVFKVNMEKEE--AD--AAMR-----DMIHL--FTNDTAAKYEG----EFVMWKVMSKFVE 117

  Fly   122 VQELIYAKDKKGKFDLLLVEQFHNEG------------ALMLGYIYEIPAITI--ATFAYANYFS 172
            ..::.:    :|.||:.|::...:..            :.::.....||.:..  ||||||  ..
Zfish   118 FGDVYF----RGLFDVGLLKTLRDSNYDVLFSDPMMPFSDLMAQKLNIPQVISMRATFAYA--AE 176

  Fly   173 QVFG-FVNPLSYVPNVFLS--CTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLL 234
            ::.| ...|.||||.|.|:  .|||||..||:||:::.    :|..:::..........::|.:|
Zfish   177 RLCGQMPAPPSYVPAVALTDHLTDRMSFMERVENMLLY----IVHSIAFPLVATFTFDGYYSEIL 237

  Fly   235 PRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA-EHGAI 298
            .:..|:.:....:.:.|:.:|.....|||...|...|||||..|.|||.:.::.::.:: :||.:
Zfish   238 GKPTTMCETMGKVDICLIRTYWDFEYPRPFPPNFKFVGGLHCKPAKPLSKELEEFVQSSGDHGVV 302

  Fly   299 YFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNV 363
            .|||||.::  ::.:|:..........:.|:|:|::.......|..|.|:..|:||.|:|.||..
Zfish   303 VFSLGSMIK--NLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKT 365

  Fly   364 KVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALL 428
            |.||.|||..|:.||:||.||::|:|.:.||..|:...:..|.|:.||..|:....|..||.|::
Zfish   366 KAFITHGGTNGLYEAIYHGVPMVGLPLFGDQPDNLLHIKTKGAAVVLDIHTMGSKDLVDALKAVV 430

  Fly   429 KDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIIL 493
            .:|.|:.::|:.|||..|:|:..:|.|:|||.:|:.::||.||......|.|||::.|||:|.:|
Zfish   431 NNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLL 495

  Fly   494 AITLLPLLTLYAVSRNYKSFRGIRAQKKEAKTE 526
            :||.| :..|:..:..:...|.:|..:.|.|.:
Zfish   496 SITAL-ITFLWVKACCFLFRRCVRKTRPERKRQ 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	159/527 (30%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	148/494 (30%)
ugt2a5	NP_001070111.2	UDPGT	21..519	CDD:278624	155/528 (29%)
ugt2a5	NP_001070111.2	egt	<249..485	CDD:223071	84/237 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585273
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.790