DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and UGT8

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001121646.2	Gene:	UGT8 / 7368	HGNCID:	12555	Length:	541	Species:	Homo sapiens

Alignment Length:	537	Identity:	158/537 - (29%)
Similarity:	275/537 - (51%)	Gaps:	52/537 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLFVCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPNYREIL 71
            :|....:|....|:|:....:..:||..:...:...|.:|||...|:  ||..::....|:..
Human     9 ILLWSAVGIAKAAKIIIVPPIMFESHMYIFKTLASALHERGHHTVFL--LSEGRDIAPSNHYS-- 69

  Fly    72 LPKY-----DTWADISAMMKTK---------SALDMIDMSKLTHMRLAQHIGIKSTDFALA-HPE 121
            |.:|     .|.:|  |.:::|         :|:::.|:  |.|.       .|:.|..:. |..
Human    70 LQRYPGIFNSTTSD--AFLQSKMRNIFSGRLTAIELFDI--LDHY-------TKNCDLMVGNHAL 123

  Fly   122 VQELIYAKDKKGKFDLLLVEQFHNEGALMLGY-IYEIPAITIATFAYANYFSQVFGFVNPLSYVP 185
            :|.|     ||.|||||||:.  |:   |.|: |..:..:..|.|:...::....|...||:|||
Human   124 IQGL-----KKEKFDLLLVDP--ND---MCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVP 178

  Fly   186 NVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVI 250
            ......||||:|.:|::|..:.....:.......|:.:.:::|:  :|||. .::..|....|:.
Human   179 EFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQKY--NLLPE-KSMYDLVHGSSLW 240

  Fly   251 LLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA-EHGAIYFSLGSQVR--SADMP 312
            :|.:.:.|..|||...|::.|||:...|..||||.::.:::.| |||.:..|.|:.|:  |.|:
Human   241 MLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDI- 304

  Fly   313 AEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQE 377
            |.||   ......|.|:|:|:|...:..||.:|.|:.:||||.|:|.|..:|.|::||||..:.|
Human   305 ANKL---AGALGRLPQKVIWRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFE 366

  Fly   378 AVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASR 442
            .:||.|||:|:|.:.|....:...||.|..|.|:::|:::.:|..||..::.:|.|:....|.|.
Human   367 TIYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNPSYRQRAQKLSE 431

  Fly   443 IFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVS-AIILAITLLPLLTLYAV 506
            |.:|:|...::..:|||:|::.|.||.||.||...:.:.|::|||:: .::|...||..|..:..
Human   432 IHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVT 496

  Fly   507 SRNYKSFRGIRAQKKEA 523
            ...|:..:.:.::.|.:
Human   497 KFIYRKIKSLWSRNKHS 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	155/514 (30%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	149/485 (31%)
UGT8	NP_001121646.2	Glycosyltransferase_GTB-type	21..502	CDD:415824	155/512 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150736
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.740