Protein Alignment Ugt49B2 and UGT2B17

DIOPT Version :9

• Sequence 1: NP_001097859.4
• Gene: Ugt49B2 / 42538
• FlyBaseID: FBgn0038886
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001068.1
• Gene: UGT2B17 / 7367
• HGNCID: 12547
• Length: 530
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 171/540 - (31%)
• Similarity: 276/540 - (51%)
• Gaps: 73/540 - (13%)

  Fly     1 MILFMKLLFVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFIT---------- 54
            |.:|:.:...|...:|...::|.   .|.: ||::....|:.|||:|||||..:|
Human     6 MSVFLLMQLSCYFSSGSCGKVLV---WPTEYSHWINMKTILEELVQRGHEVIVLTSSASILVNAS 67

  Fly    55 ----------PLSLAKENLGPNYREILLPKYDTWADISAMMKTKSALDMIDMSKLT---HMRLAQ 106
                      |.||.|.:|    .:..:..:|.|.              ..:||.|   :....|
Human    68 KSSAIKLEVYPTSLTKNDL----EDFFMKMFDRWT--------------YSISKNTFWSYFSQLQ 114

  Fly   107 HIGIKSTDFALAHPE---VQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYA 168
            .:..:.:|:.:...|   :.:.:..|.::.|||:||.:..:..|.| |..:..||      |.|:
Human   115 ELCWEYSDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGEL-LAELLNIP------FLYS 172

  Fly   169 NYFSQVF-------GFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVI 226
            ..||..:       ||:.|.||||.|....:|:|...||::|::.....|...:.....:.|
Human   173 LRFSVGYTVEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWD--- 234

  Fly   227 RKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLD 291
             :.:|.:|.|..|:.:......:.|:.:|.....|||...|:..|||||..|.||||:.::.::.
Human   235 -QFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQ 298

  Fly   292 NA-EHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPN-LPDNVKVEKWLPQ 354
            :: |:|.:.|||||.:  ::|..|...:.....|.:.|:|||:| |.:.|| |..|.::.|||||
Human   299 SSGENGIVVFSLGSMI--SNMSEESANMIASALAQIPQKVLWRF-DGKKPNTLGSNTRLYKWLPQ 360

  Fly   355 ADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQ 419
            .|:|.||..|.||.|||..|:.||:||.:|::|:|.:.||..||...:|.|.|:.:|.||:|...
Human   361 NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRD 425

  Fly   420 LKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFY 484
            |.:||.:::.||.|:.|:||.|||..|:|:..:|.|::||.:|:.|:||.||..|..:|.|.|::
Human   426 LLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYH 490

  Fly   485 LLDVSAIILA--ITLLPLLT 502
            .|||.|.:||  .|::.::|
Human   491 SLDVIAFLLACVATMIFMIT 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	170/538 (32%)
		UDPGT	31..497	CDD:278624	163/502 (32%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	167/522 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150301
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790