Protein Alignment Ugt49B2 and UGT2B15

DIOPT Version :10

• Sequence 1: NP_001097859.4
• Gene: Ugt49B2 / 42538
• FlyBaseID: FBgn0038886
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001067.2
• Gene: UGT2B15 / 7366
• HGNCID: 12546
• Length: 530
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 178/577 - (30%)
• Similarity: 282/577 - (48%)
• Gaps: 107/577 - (18%)

  Fly     3 LFMKLLFVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFIT------------ 54
            :|:.:...|...:|...::|.   .|.: ||::....|:.|||:||||||.:|
Human     8 VFLLIQLSCYFSSGSCGKVLV---WPTEYSHWINMKTILEELVQRGHEVTVLTSSASTLVNASKS 69

  Fly    55 --------PLSLAKENLGPNYRE-ILLPKYDTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGI 110
                    |.||.|     ||.| .||...|.|.                            .|:
Human    70 SAIKLEVYPTSLTK-----NYLEDSLLKILDRWI----------------------------YGV 101

  Fly   111 KSTDFALAHPEVQELIY---------AKD-----------KKGKFDLLLVEQFHNEGALMLGYIY 155
            ....|.....::|||.:         .||           ::.|||::|.:..:..|.| |..::
Human   102 SKNTFWSYFSQLQELCWEYYDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGEL-LAELF 165

  Fly   156 EIPAITIATFAYANYFSQVF-------GFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVV 213
            .||      |.|:..||..:       ||:.|.||||.|....:|:|...||::|::.....|..
Human   166 NIP------FLYSLRFSVGYTFEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFW 224

  Fly   214 REVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILP 278
            .::....:.|    :.:|.:|.|..|:.:......:.|:.:|.....|||...|:..|||||..|
Human   225 FQIYDLKKWD----QFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKP 285

  Fly   279 PKPLPEHIKNYLDNA-EHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPN- 341
            .||||:.::.::.:: |:|.:.|||||.:  ::|..|...:.....|.:.|:|||:| |.:.||
Human   286 AKPLPKEMEEFVQSSGENGIVVFSLGSMI--SNMSEESANMIASALAQIPQKVLWRF-DGKKPNT 347

  Fly   342 LPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGY 406
            |..|.::.|||||.|:|.||..|.||.|||..|:.||:||.:|::|:|.:.||..||...:|.|.
Human   348 LGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGA 412

  Fly   407 AIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHL 471
            |:.:|.||:|...|.:||.:::.||.|:.|:||.|||..|:|:..:|.|::||.:|:.|:||.||
Human   413 ALSVDIRTMSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHL 477

  Fly   472 VAAGVHLPWYQFYLLDVSAIILA--ITLLPLLTLYAVSRNYKSFRGIRAQKKEAKTE 526
            ..|..:|.|.|::.|||.|.:||  .|::.::|.:.:.    .||.:..:.|:.|.:
Human   478 RVAAHNLTWIQYHSLDVIAFLLACVATVIFIITKFCLF----CFRKLAKKGKKKKRD 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	Glycosyltransferase_GTB-type	31..497	CDD:471961	167/517 (32%)
UGT2B15	NP_001067.2	UDPGT	24..518	CDD:278624	171/547 (31%)