Protein Alignment Ugt49B2 and UGT2B7

DIOPT Version :9

• Sequence 1: NP_001097859.4
• Gene: Ugt49B2 / 42538
• FlyBaseID: FBgn0038886
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001065.2
• Gene: UGT2B7 / 7364
• HGNCID: 12554
• Length: 529
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 167/567 - (29%)
• Similarity: 274/567 - (48%)
• Gaps: 106/567 - (18%)

  Fly     1 MILFMKLLFVCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTF------------- 52
            :||.::|.| | ..:|:..::|.  :....||:|....|:.||::||||||.
Human     8 VILLIQLSF-C-FSSGNCGKVLV--WAAEYSHWMNIKTILDELIQRGHEVTVLASSASILFDPNN 68

  Fly    53 -------ITPLSLAKENLGPNYREILLPKYDTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGI 110
                   |.|.||.|..|    ...::.:...|:|:.
Human    69 SSALKIEIYPTSLTKTEL----ENFIMQQIKRWSDLP---------------------------- 101

  Fly   111 KSTDFALAHPEVQELI---------YAKD-----------KKGKFDLLLVEQFHNEGALMLGYIY 155
            |.| |.|...:|||::         :.||           ::.:||::..:.......| |..::
Human   102 KDT-FWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKVQESRFDVIFADAIFPCSEL-LAELF 164

  Fly   156 EIPAITIATFAYANYFSQVF-------GFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVV 213
            .||      |.|:..||..:       ||:.|.||||.|....||:|:..||::|::.....|..
Human   165 NIP------FVYSLSFSPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFW 223

  Fly   214 REVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILP 278
            .|:....:.|    :.:|.:|.|..|:.:......|.|:.:......|.|:..|:..|||||..|
Human   224 FEIFDMKKWD----QFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKP 284

  Fly   279 PKPLPEHIKNYLDNA-EHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNL 342
            .||||:.:::::.:: |:|.:.|||||.|  ::|..|:..:.....|.:.|:|||:|:.::...|
Human   285 AKPLPKEMEDFVQSSGENGVVVFSLGSMV--SNMTEERANVIASALAQIPQKVLWRFDGNKPDTL 347

  Fly   343 PDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYA 407
            ..|.::.||:||.|:|.||..:.||.|||..|:.||:||.:|::|:|.:.||..||...:|.|.|
Human   348 GLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAA 412

  Fly   408 IGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLV 472
            :.:|:.|:|...|.:||..::.||.|:.|:||.|||..|:|:..:|.|::||.:|:.|:||.||.
Human   413 VRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLR 477

  Fly   473 AAGVHLPWYQFYLLD--------VSAIILAITLLPLLTLYAVSRNYK 511
            .|...|.|:|::.||        |:.:|..:|...|...:..:|..|
Human   478 VAAHDLTWFQYHSLDVIGFLLVCVATVIFIVTKCCLFCFWKFARKAK 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	165/556 (30%)
		UDPGT	31..497	CDD:278624	156/521 (30%)
UGT2B7	NP_001065.2	UDPGT	24..525	CDD:278624	161/549 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150706
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790