DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and Ugt2b1

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_690024.1	Gene:	Ugt2b1 / 71773	MGIID:	1919023	Length:	529	Species:	Mus musculus

Alignment Length:	533	Identity:	162/533 - (30%)
Similarity:	259/533 - (48%)	Gaps:	83/533 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LFMKLLFVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPN 66
            :|:.:.|:|.:..|...::|.   .|.: ||::....|:.|||:|||:||.:  :|.|...:||:
Mouse     8 VFLLIQFICYIRPGACGKVLV---WPTEYSHWINMKIILDELVQRGHDVTVL--ISSASILIGPS 67

  Fly    67 YREIL----------------------------LPKYDTWADISAMMKTKSAL-DMIDMSKLTHM 102
            ....:                            |.|...|...|.:.|..|.. |||:
Mouse    68 NESSINFEIYSAPLSKDDLEYAFEKWVGNWTYELKKLPFWTSYSKLQKISSEYSDMIE------- 125

  Fly   103 RLAQHIGIKSTDFALAHPEVQELIYAKD--KK---GKFDLLLVEQFHNEGALMLGYIYEIPAITI 162
                       .|..|      :::.|.  ||   .|||::|.:.....|.| |..:.:.|.:..
Mouse   126 -----------SFCKA------VVWNKSLMKKLQGSKFDVVLADALVPCGEL-LSELLKTPLVYS 172

  Fly   163 ATFAYANYFSQVF--GFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAED----VVREVSYYPQ 221
            ..|. ..|..:.:  |...|.||||.|....:|.|:..||::|::.....|    ...|.|:
Mouse   173 LRFC-PGYKCEKYSGGLPLPPSYVPVVLSELSDHMTFAERVKNMLQVLLFDFWFQTFNEKSW--- 233

  Fly   222 QDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHI 286
                 .:.:|.:|.|..|:.::.....:.|:.::..|..|.|...|...|||||..|.||||:.:
Mouse   234 -----NQFYSDVLGRPTTLTEMMGKADIWLVRTFWDLKFPHPFLPNFDFVGGLHCKPAKPLPKEM 293

  Fly   287 KNYLDNA-EHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEK 350
            :.::.:: |||.:.|||||.|:  ::..||..:.....|.:.|:|||:|:..:...|..|.::.|
Mouse   294 EEFVQSSGEHGVVVFSLGSMVK--NIKEEKANVVASALAQIPQKVLWRFDGKKPDTLGSNTRLYK 356

  Fly   351 WLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTI 415
            |:||.|:|.||..|.||||||..|:.||:||.:|::|:|.:.||..||....|.|.|:.:|:.|:
Mouse   357 WIPQNDLLGHPKTKAFIAHGGTNGIYEAIYHGIPIVGIPLFGDQPDNINHIVAKGAAVRVDFDTM 421

  Fly   416 SKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPW 480
            |...|.:||..::.||.|:.|.|:.|||..|:|:..:|.|::||.||:.::||.||..|...|.|
Mouse   422 STTDLLTALKTVINDPSYKENAMRLSRIHHDQPMKPLDRAVFWIEYVMRNKGAKHLRPALHDLTW 486

  Fly   481 YQFYLLDVSAIIL 493
            :|::.|||...:|
Mouse   487 FQYHSLDVIGFLL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	162/533 (30%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	156/504 (31%)
Ugt2b1	NP_690024.1	egt	8..508	CDD:223071	162/533 (30%)
Ugt2b1	NP_690024.1	UDPGT	24..527	CDD:278624	158/517 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840790
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.790