DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt2a1

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_038948318.1	Gene:	Ugt2a1 / 63867	RGDID:	69432	Length:	528	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	155/487 - (31%)
Similarity:	254/487 - (52%)	Gaps:	43/487 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGP----NYREILLPKYDTWADISAMMKTKSAL 91
            ||::....::.|||:|.|.||.:........|..|    ::.||  |...|.:.|..|::...||
  Rat    32 SHWLNIKILLEELVQRNHSVTVLAASETLFINSSPDAFISFEEI--PVSYTRSKIDEMIEHMIAL 94

  Fly    92 DMID--MSKLTHMRLAQHIGIKSTDFALAHPEV------QELIYAKDKKGKFDLLLVEQFHNEG- 147
             .:|  .:.||.....:.:|.....|...:.::      ...:.|:.:||.||:|:.:.....|
  Rat    95 -WLDHRPTPLTMWAFYKELGKLFAAFYKINKQICDGVLKNATLMARLQKGGFDVLISDPVTMCGE 158

  Fly   148 --ALMLGYIYEIPAITIATFAYANYFSQVF------GFV-NPLSYVPNVFLSCTDRMSLWERLEN 203
              ||.||    ||      |.|...||..|      |.: .|:||||......||:|:..||::|
  Rat   159 LVALKLG----IP------FVYTLRFSPAFTVERHCGKIPTPVSYVPAALSELTDQMTFGERVKN 213

  Fly   204 VVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNM 268
            .:..:.:|.:.: ||:.:.::    ::|.:|.|..|:.:......:.|:.:|.....|||...|.
  Rat   214 TISYSLQDYIFK-SYWGEWNS----YYSRVLGRPTTLCETMGKAEIWLMRTYWDFEFPRPYLPNF 273

  Fly   269 ISVGGLHILPPKPLPEHIKNYLD-NAEHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLW 332
            ..|||||..|.||||:.::.::. :.|||.:.|||||.|:  ::..||..:.....|.:.|:|||
  Rat   274 EFVGGLHCKPAKPLPKEMEEFVQTSGEHGVVVFSLGSMVK--NLTEEKANLIASALAQIPQKVLW 336

  Fly   333 KFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDIN 397
            :::......|..|.::..|:||.|:|.||..:.||.|||..|:.||:||.:|::|:|.:.||..|
  Rat   337 RYKGKIPATLGSNTRLFDWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPMVGVPMFADQPDN 401

  Fly   398 IKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYV 462
            |...:|.|.|:.::..|::...|.||:.|::.:|.|:.|.|:.|||..|:|:..:|.|::||.:|
  Rat   402 IAHMKAKGAAVEVNMNTMTSADLLSAVRAVINEPFYKENAMRLSRIHHDQPVKPLDRAVFWIEFV 466

  Fly   463 VEHRGAPHLVAAGVHLPWYQFYLLDVSAIILA 494
            :.|:||.||..|...|.|:|::.|||...:||
  Rat   467 MRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLA 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	155/487 (32%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	155/487 (32%)
Ugt2a1	XP_038948318.1	UDPGT	22..524	CDD:278624	155/487 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860