DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt305A1

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001261394.1	Gene:	Ugt305A1 / 59217	FlyBaseID:	FBgn0042179	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	118/539 - (21%)
Similarity:	214/539 - (39%)	Gaps:	116/539 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KLLFVCLLGTGDGARIL--AP-------------FFLP-----VKSHFMMTDAIIRELVKRGHEV 50
            |.||..||..|....::  ||             :.||     :|.||::.:.  ||.:    .:
  Fly    40 KPLFDALLANGHSLLVISTAPNPEPKKQVDGLVYYHLPNEYDVMKRHFLLEEP--REYI----SM 98

  Fly    51 TFITPLSLAKENLGPNYREILLPKYDTWA----DISAMMKTKSALDMID--------MSKLTHMR 103
            ..:..|.:..|.|..:.|.:|  ..||.:    :::|.:..:..|.:.|        |..::..|
  Fly    99 VTLNQLLVWYEVLLGSCRALL--NSDTMSSKRPELTAQLSMEYDLIITDVTQGIECLMDSVSGWR 161

  Fly   104 LAQHIGIKSTDFALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYA 168
            ....:|:.:....   |::..|:.|::                              ||......
  Fly   162 SKPVLGLSAGKLT---PDLMSLLRAEN------------------------------TINAARIP 193

  Fly   169 NYFSQVFGFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSL 233
            :|.||          ||..       |..|.||.|.::..||.::..|        :.|...|.|
  Fly   194 HYISQ----------VPKT-------MGFWNRLHNHIMYYAEPLIHLV--------ITRPVLSEL 233

  Fly   234 LPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHIL-PPKPLPEHIKNYLDNAEHGA 297
            :.......:|:    ::|||::..|...:.:...:|.||||||. ...|||.:|:.:.:....|.
  Fly   234 MKTENAFPKLQ----LVLLNTHPTLDYVQNLPPGVIEVGGLHIKNQTSPLPTYIQEFTEKFFDGI 294

  Fly   298 IYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFED-DQLPNLPDN---VKVEKWLPQADIL 358
            :|.::.......|...:.:  :..:..:.....:|..|. :|||....|   :.|.:.| |.|||
  Fly   295 VYINMPYIEYMNDQGLKAM--YTMIHGNPNVAFIWNVEQLEQLPAKKPNLLTLHVNQSL-QQDIL 356

  Fly   359 AHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSA 423
            |...||.|:.||..|.:|||:::.|||:.:|...::..|.:........:.|..:..::..|..|
  Fly   357 AMQYVKGFLNHGDSFSLQEAIHYGVPVVVLPLKLEEFNNAQRVMERNLGVMLQVKEFNQSSLSDA 421

  Fly   424 LHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVV-EHRGAPHLVAAGVHLPWYQFYL-- 485
            |..:|.:.::.:.:.:|...||.||..|::.|::....:: |.|...|.  |........|::
  Fly   422 LTRILDEERFISALHQAQLKFRTRPQSALELAVWHAEQLIAEPRLFKHF--AQTETLAQNFFVAN 484

  Fly   486 -LDVSAIILAITLLPLLTL 503
             |||..:.|.:.|..:::|
  Fly   485 SLDVLTVPLIVLLAAVVSL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	117/536 (22%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	105/486 (22%)
Ugt305A1	NP_001261394.1	Glycosyltransferase_GTB_type	<242..461	CDD:299143	58/225 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454767
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.990