DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt5g1

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001107914.1	Gene:	ugt5g1 / 570913	ZFINID:	ZDB-GENE-080305-10	Length:	528	Species:	Danio rerio

Alignment Length:	543	Identity:	150/543 - (27%)
Similarity:	255/543 - (46%)	Gaps:	62/543 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CLLGT---GDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTF------------------IT 54
            |||..   ..|..||.  |....||::....|:|:|...||..|.                  ||
Zfish    13 CLLSVVCCCHGGNILV--FPEDGSHWVNMQVILRKLHTHGHSFTVVRSSKSWYIHENSALYNTIT 75

  Fly    55 PLSLAKENLGPNYREILLPKYDTWADISAMMKTKSAL--------DMIDMSKLTHMRLAQHIGIK 111
            ...:..|::|.:|..:||       |.|..::..|.|        |:..:.|:.|..:.:.:...
Zfish    76 VNPVETEDVGQDYFNMLL-------DRSLALQKMSPLVRFFEQQKDITTVLKVFHNGVLRMVSAM 133

  Fly   112 STDFALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFG 176
            ..|..|    |:.|     ::.||||||.:.....|.|:..:: ::|.:....:..|. .:.:..
Zfish   134 LDDAEL----VKSL-----REAKFDLLLTDPAFPAGVLVANFL-QLPMVYNVRWLNAG-DAHMQT 187

  Fly   177 FVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHF---SSLLPRVP 238
            ..:|.||||.......|:||..:|:||.:......:.......|....::.:||   |.||
Zfish   188 APSPPSYVPMYNSLLHDQMSFLQRVENFLRYLCSLLQERYVIVPIYRELLERHFPPGSDLL---- 248

  Fly   239 TVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA-EHGAIYFSL 302
               .::|:..:.|:........|||...|:|.:||....|.:.||..::.::.:: |||.::.||
Zfish   249 ---SMQQSADIWLMRMDFVFDFPRPTMPNIIYMGGFQCKPAQALPVDLEEFMQSSGEHGVVFMSL 310

  Fly   303 GSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFI 367
            |:.|.:  :|....:.....||.:.|:|:|::..::...|.:|..:.:|.||.|:|.||..:.|:
Zfish   311 GAMVGA--LPRTITEAIASAFAKIPQKVMWRYHGERPSTLGNNTLLLEWFPQNDLLGHPKTRAFV 373

  Fly   368 AHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPK 432
            :|||..|:.||:||.||||.:|..|||..|:...|....|..|...|::..:....|..:|::|.
Zfish   374 SHGGTNGIYEAIYHGVPVLALPLLFDQFDNVMRLQVRNAARVLQVATLTSQEFLEGLKDVLENPL 438

  Fly   433 YQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITL 497
            |::::.|.|.:.||:|:..:|:|.:||.||:.|:||.||.:...:|.||.::.|||...:|||.:
Zfish   439 YRSSIRKMSELHRDQPISPLDSATFWIEYVMRHKGAAHLRSEANNLAWYSYHSLDVLVFLLAIAV 503

  Fly   498 LPLLTLYAVSRNYKSFRGIRAQK 520
            :...|...|.|.....:.|:.:|
Zfish   504 IAFWTSVYVCRFLCCRKSIKKRK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	145/523 (28%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	138/495 (28%)
ugt5g1	NP_001107914.1	UDPGT	24..526	CDD:278624	145/530 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585222
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790