DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt5c3

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001122186.1	Gene:	ugt5c3 / 563413	ZFINID:	ZDB-GENE-050419-23	Length:	531	Species:	Danio rerio

Alignment Length:	550	Identity:	158/550 - (28%)
Similarity:	278/550 - (50%)	Gaps:	73/550 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFI--TPLSLAKENLGPNYREI 70
            |:|     ||.:||.   :|:: ||::..|.:|:.|..:||.:..|  |.....||. ...|..|
Zfish    23 FLC-----DGGKILV---VPLEGSHWLNMDILIKALHGKGHSIDVIRNTNSWYVKEK-SDYYNSI 78

  Fly    71 LLPKY----DTWAD--ISAMMKTK---------------SALDMIDMSKLTHMRLAQHIGIKSTD 114
            .:|:.    :.:.|  ||.::..:               |.:|..:|:|:.            .|
Zfish    79 TIPQSKGMDEEFVDDMISKVINHERGKSSWLSTVKLFFDSVIDNYEMTKMV------------CD 131

  Fly   115 FALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAY-ANYFSQVFGFV 178
            ...:..|.:|::....:| ::||:|.:.....| ::|.:..::|.:      | ..:.:.|.|..
Zfish   132 ITTSIFESEEILKTLQEK-QYDLMLTDPVWGMG-IILAHKLKLPMV------YNVRWTTTVDGHF 188

  Fly   179 N----PLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPT 239
            |    |:||:|......|||||.::|::|::.....|:.......||..|:..|:|.      |.
Zfish   189 NIAPSPMSYIPITGSGNTDRMSFFQRVKNIIFYFTNDIKYSRFSLPQYQAICDKYFD------PP 247

  Fly   240 VK--QLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA-EHGAIYFS 301
            |.  ||.|...:.|:........|||...|:|..||....|.||||..:::::.:: :||.|..|
Zfish   248 VDFYQLLQGADIWLMRVDFVFEFPRPTMPNIIYTGGFQCTPAKPLPHDLEDFMQSSGDHGVIVMS 312

  Fly   302 LGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVF 366
            ||:.:.:  :|.:........||.|.|:|:|::...:...|.:|..:..|:||.|:|.||..|||
Zfish   313 LGTFISA--LPEDVTAEIAAAFARLPQKVIWRYTGKKPSTLGNNTLLVDWMPQKDLLGHPKTKVF 375

  Fly   367 IAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDP 431
            :||||..|:|||:||.|||:|:||:|||..|:...||.|.|..:....:.::.|.:|:..::.:|
Zfish   376 VAHGGTNGVQEALYHGVPVVGIPFFFDQYDNLIRLQARGGAKIVSLAELGENSLHAAIKEVINNP 440

  Fly   432 KYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAIT 496
            .|:..|.|.|::..|:|:..:|:|::||.:|:.|:||.||......:|||.::.:||:..::|:.
Zfish   441 SYRLTMQKLSQLHLDKPVKPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVAVTLIAVV 505

  Fly   497 LLPLLTLYAVSRNYKSFRGIRAQKKEAKTE 526
            |:.:.:::.|.|    :..|:...::.|||
Zfish   506 LIFIFSIFYVVR----YVCIKCCSRKRKTE 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	152/524 (29%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	144/496 (29%)
ugt5c3	NP_001122186.1	UDPGT	28..530	CDD:278624	151/537 (28%)
ugt5c3	NP_001122186.1	egt	<267..507	CDD:223071	86/241 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585281
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790