DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and ugt5g2

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001186305.1	Gene:	ugt5g2 / 556049	ZFINID:	ZDB-GENE-081028-66	Length:	534	Species:	Danio rerio

Alignment Length:	555	Identity:	156/555 - (28%)
Similarity:	270/555 - (48%)	Gaps:	69/555 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MKLLFV---CLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGP 65
            |.|:|:   .||....|.........|:. ||::..:.::::|..||||::.|.
Zfish     5 MSLVFLWTSLLLSLPSGYNADKILVFPIDGSHWVNMEVLVKKLQSRGHELSVIR----------- 58

  Fly    66 NYREILLPKYDTW---------ADISAMMKTKSA-LDMID--MSKLTHMR-----------LAQH 107
                    ..|:|         :.|:..:|.|.. ||:.:  :.|:...|           :::.
Zfish    59 --------LEDSWFIKGNSPYYSSITVTLKKKFIDLDLFETAVKKILDARRDGPIMGVLAQMSEF 115

  Fly   108 IGI----KSTDFALAHPEVQ-ELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAY 167
            |||    ...:.|:....:: :::.::.|...:||:|.:.....|.::..|::......:...::
Zfish   116 IGILKVGHGANIAMLTSMLENKVLMSQIKMANYDLMLTDPAMPGGVILAHYLHLPMVYNVRWMSF 180

  Fly   168 A-NYFSQVFGFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFS 231
            . .:||..   .:|:|:||......||||.|.||..|.:......:.......|...:::..||
Zfish   181 GEGHFSIA---PSPISFVPVPGSGLTDRMGLLERSRNFLHYGLNLIQERWMVIPMYTSLLLNHF- 241

  Fly   232 SLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA-EH 295
               |....:..::::..:.|:.:......|||...|::.:||....|.||||..::.::.:: :|
Zfish   242 ---PPGTDLLTMQRSAELWLVRADFVFEFPRPSMPNLVYIGGFQCRPAKPLPADLEEFMQSSGDH 303

  Fly   296 GAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAH 360
            |.:..|||:.:  |.:|.|.::.....||.:.|:|:|:|...:...|.:|..:.:||||.|:|.|
Zfish   304 GVVVMSLGTLI--AGLPKEVMEAIASAFAQIPQKVIWRFIGQRPSTLGNNTLLIQWLPQNDLLGH 366

  Fly   361 PNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALH 425
            |..:.|:||||..|:.||:||.|||||:|..|||..||...||.|.|..||..|.|..:...||.
Zfish   367 PKTRAFVAHGGTNGLYEAIYHGVPVLGLPLLFDQLDNIVRLQARGGARMLDAATCSTKEFLVALT 431

  Fly   426 ALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSA 490
            .:|::|.|:.||.|.|.:.|||||..:|.|:|||.:|:.::|||||.|...::..:.:|.|||.|
Zfish   432 DILENPTYRQNMQKLSNLHRDRPLHPLDKAVYWIEFVLRNKGAPHLRAEAYNVSEFSYYCLDVVA 496

  Fly   491 IILAITLLPLLTLYAVSRNYKSFRGIRAQKKEAKT 525
            ::|.:.|..|..:|.:.:.       |.:::|.||
Zfish   497 LVLFMLLGTLGGVYTICKR-------RPKRQENKT 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	151/530 (28%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	142/495 (29%)
ugt5g2	NP_001186305.1	egt	3..507	CDD:223071	150/529 (28%)
ugt5g2	NP_001186305.1	UDPGT	25..513	CDD:278624	146/515 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585225
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790