DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt2a2

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001018306.2	Gene:	ugt2a2 / 553952	ZFINID:	ZDB-GENE-080721-21	Length:	534	Species:	Danio rerio

Alignment Length:	525	Identity:	149/525 - (28%)
Similarity:	255/525 - (48%)	Gaps:	57/525 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SHFMMTDAIIRELVKRGHEVT----------------------FITPLSLAKENLGPNYREILLP 73
            ||:.....::.||:.|.|.||                      |..||| |:|..|.:...|.:
Zfish    33 SHWQNMRNVVDELLNRNHTVTVLVCSASPTINFTQQERFQYLVFEVPLS-AQELDGASEELIHI- 95

  Fly    74 KYDTWADISAMMKTKSALDMID-MSKLTHMRLAQHIGIKSTDFALAHPEVQELIYAKDKKGKFDL 137
                |....:..:.::||.:|: :.::..|..|....:...|..:|  ::..|        |||:
Zfish    96 ----WTQHPSPNRLQTALQIIELLGRVRVMHRAMCDSMLRNDALIA--QLSAL--------KFDV 146

  Fly   138 LLVEQFHNEGALM----LGYIYEIPAITIATFAYANYFSQVFG-FVNPLSYVPNVFLSCTDRMSL 197
            |.     |:...|    |..:..:|.:.....:......::.| ...|.|:||......||||..
Zfish   147 LF-----NDPMFMCADLLAEMLGLPLVLSVRISPGFCLERMCGQMPAPPSFVPITQTVLTDRMCF 206

  Fly   198 WERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPR 262
            .||::|::    .::|..||:|......:..:::.:|.:..|:.:......:.|:.:|.....||
Zfish   207 MERVQNMI----ANIVFSVSFYIVAWISLDSYYTDVLGKPTTMCETMGKADIWLIRTYWDFEYPR 267

  Fly   263 PMSQNMISVGGLHILPPKPLPEHIKNYLDNA-EHGAIYFSLGSQVRSADMPAEKLQIFLDVFASL 326
            |...|...|||||..|.|||.:.::.::.:: :||.:.|||||.::  ::.:|:..........:
Zfish   268 PFPPNFKFVGGLHCKPAKPLSKEMEEFVQSSGDHGVVVFSLGSMIK--NLTSERANTIAAALGQI 330

  Fly   327 KQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFY 391
            .|:|:|::.......|..|.|:..|:||.|:|.||..|.||.|||..|:.||:||.||::|:|.:
Zfish   331 PQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLF 395

  Fly   392 FDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAM 456
            .||..|:...:..|.|:.||..|:....|..||..:|.:|.|:.::|:.|||..|:|:..:|.|:
Zfish   396 ADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAV 460

  Fly   457 YWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITLLPLLTLYAVSRNYKSFRGIRAQKK 521
            |||.:|:.::||.||......|.|||::.|||:|.:|:|..| :..|:..:..:...|.:|..:.
Zfish   461 YWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSIAAL-ITFLWVKACCFLFRRCVRKTRP 524

  Fly   522 EAKTE 526
            |.||:
Zfish   525 ERKTQ 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	143/499 (29%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	142/494 (29%)
ugt2a2	NP_001018306.2	UDPGT	23..521	CDD:278624	145/515 (28%)
ugt2a2	NP_001018306.2	egt	<256..487	CDD:223071	84/232 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860