DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and UGT1A4

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_009051.1	Gene:	UGT1A4 / 54657	HGNCID:	12536	Length:	534	Species:	Homo sapiens

Alignment Length:	523	Identity:	144/523 - (27%)
Similarity:	250/523 - (47%)	Gaps:	81/523 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 IRELVKRGHEVTFITP---LSLAKENL------------------------GPNYREILLPKYDT 77
            :|||..|||:...:||   :.:.:|..                        |....|.||.:|.
Human    48 LRELHARGHQAVVLTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYS- 111

  Fly    78 WADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDFALAHPEVQELIYAKDKKGKFDLLLVEQ 142
             ..::.|.....||....:..|.:..|.:|:...|                      ||::|.:.
Human   112 -RSMAIMNNVSLALHRCCVELLHNEALIRHLNATS----------------------FDVVLTDP 153

  Fly   143 FHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPLSYVPNVFLSCTDRMSLWERLENVVIS 207
            .:..||::..|: .|||:....:...:...:.....||.||:|.:..:.:|.|:..:|::|::
Human   154 VNLCGAVLAKYL-SIPAVFFWRYIPCDLDFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNML-- 215

  Fly   208 TAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQL-EQNISVILLNSY---------MPLTSPR 262
                       ||...:.|...||:  |......:| ::.:||:.|.||         ..:..||
Human   216 -----------YPLALSYICHTFSA--PYASLASELFQREVSVVDLVSYASVWLFRGDFVMDYPR 267

  Fly   263 PMSQNMISVGGLHILPPKPLPEHIKNYLD-NAEHGAIYFSLGSQVRSADMPAEKLQIFLDVFASL 326
            |:..||:.:||::....|||.:..:.|:: :.|||.:.|||||.|  :::|.:|.....|....:
Human   268 PIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKI 330

  Fly   327 KQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFY 391
            .|.|||::...:..||.:|..:.|||||.|:|.||..:.||.|.|..|:.|::.:.||::.||.:
Human   331 PQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLF 395

  Fly   392 FDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAM 456
            .||..|.|..:..|..:.|:...::.:.|::||.|::.|..|:.|:|:.|.:.:|||:..:|.|:
Human   396 GDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAV 460

  Fly   457 YWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITL-LPLLTLYAVSRNYKSFRGIRAQK 520
            :|:.:|:.|:|||||..|...|.|||::.|||...:||:.| :..:|....:..|:...|.:.:.
Human   461 FWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRV 525

  Fly   521 KEA 523
            |:|
Human   526 KKA 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	139/500 (28%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	138/494 (28%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	142/518 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150725
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790