Protein Alignment Ugt49B2 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_001097859.4
• Gene: Ugt49B2 / 42538
• FlyBaseID: FBgn0038886
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 145/515 - (28%)
• Similarity: 251/515 - (48%)
• Gaps: 47/515 - (9%)

  Fly    31 SHFMMTDAIIRELVKRGHEVTFIT---PLSLAKENLGPNYREILLPKYD-TWADISAMMKTKSAL 91
            ||::.....:|:|..|||:|..:|   .:.:.:||.      ..|..|. :|..
Human    39 SHWLSMREALRDLHARGHQVVVLTLEVNMYIKEENF------FTLTTYAISWTQ----------- 86

  Fly    92 DMIDMSKLTH-----------MRLAQHIGIKSTDFALAHPEVQELIYAKD-----KKGKFDLLLV 140
            |..|...|.|           |:.::.:.|.:....:.|....||::.:.     ....||::|.
Human    87 DEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNMSLIIHRSCVELLHNEALIRHLHATSFDVVLT 151

  Fly   141 EQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPLSYVPNVFLSCTDRMSLWERLENVV 205
            :.||...|::..|: .|||:........:...:.....||.||:|.:..:.:|.|:..:|::|::
Human   152 DPFHLCAAVLAKYL-SIPAVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFLQRVKNML 215

  Fly   206 ISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMIS 270
            ...|...:......|.....     |.|..|..:|..|..:.||.|......:..|||:..||:.
Human   216 YPLALSYLCHAVSAPYASLA-----SELFQREVSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVF 275

  Fly   271 VGGLHILPPKPLPEHIKNYLD-NAEHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKF 334
            :||::....|||.:..:.|:: :.|||.:.|||||.|  :::|.:|.....|....:.|.|||::
Human   276 IGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRY 338

  Fly   335 EDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIK 399
            ...:..||.:|..:.|||||.|:|.||..:.||.|.|..|:.|::.:.||::.||.:.||..|.|
Human   339 TGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAK 403

  Fly   400 AGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVE 464
            ..:..|..:.|:...::.:.|::||.|::.|..|:.|:|:.|.:.:|||:..:|.|::|:.:|:.
Human   404 RMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMR 468

  Fly   465 HRGAPHLVAAGVHLPWYQFYLLDVSAIILAITL-LPLLTLYAVSRNYKSFRGIRAQKKEA 523
            |:|||||..|...|.|||::.|||...:||:.| :..:|....:..|:...|.:.:.|:|
Human   469 HKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKA 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	140/492 (28%)
		UDPGT	31..497	CDD:278624	139/486 (29%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	143/510 (28%)
		egt	<262..508	CDD:223071	88/247 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150724
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.890