DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ugt49B2 and UGT1A6

DIOPT Version :9

Sequence 1:NP_001097859.4 Gene:Ugt49B2 / 42538 FlyBaseID:FBgn0038886 Length:526 Species:Drosophila melanogaster
Sequence 2:NP_001063.2 Gene:UGT1A6 / 54578 HGNCID:12538 Length:532 Species:Homo sapiens


Alignment Length:551 Identity:149/551 - (27%)
Similarity:264/551 - (47%) Gaps:73/551 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LLFVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFITP--LSLAKENL----- 63
            :.|:.|.|...|.::|.   :|.. ||::....|:..|..||||:..:.|  ..|.||:.     
Human    15 VFFLALWGMVVGDKLLV---VPQDGSHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRK 76

  Fly    64 ---GPNYREILLPKYDTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDF-------ALA 118
               .|..:|.|..:|.::.:                   .|......:....|::       .|.
Human    77 IYPVPYDQEELKNRYQSFGN-------------------NHFAERSFLTAPQTEYRNNMIVIGLY 122

  Fly   119 HPEVQELIYAKD-----KKGKFDLLLVEQFHNEGALMLGYIYEIPAITI---------ATFAYAN 169
            ....|.|:..:|     |:.|||.|..:.....|.::..|: .:|::.:         .||:.: 
Human   123 FINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYL-GLPSVYLFRGFPCSLEHTFSRS- 185

  Fly   170 YFSQVFGFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLL 234
                    .:|:||:|..:...:|.|:..:|:.|.:::..|..:....:...::..     |::|
Human   186 --------PDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELA-----SAVL 237

  Fly   235 PRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLD-NAEHGAI 298
            .|...:..|.|.:||.||.....|..|||:..||:.:||::....|.|.:..:.|:: :.|||.:
Human   238 KRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHGIV 302

  Fly   299 YFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNV 363
            .|||||.|  :::|.:|.....|....:.|.|||::...:..||.:|..:.|||||.|:|.||..
Human   303 VFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMT 365

  Fly   364 KVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALL 428
            :.||.|.|..|:.|::.:.||::.||.:.||..|.|..:..|..:.|:...::.:.|::||.|::
Human   366 RAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVI 430

  Fly   429 KDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIIL 493
            .|..|:.|:|:.|.:.:|||:..:|.|::|:.:|:.|:|||||..|...|.|||::.|||...:|
Human   431 NDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLL 495

  Fly   494 AITL-LPLLTLYAVSRNYKSFRGIRAQKKEA 523
            |:.| :..:|....:..|:...|.:.:.|:|
Human   496 AVVLTVAFITFKCCAYGYRKCLGKKGRVKKA 526

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ugt49B2NP_001097859.4 egt 1..502 CDD:223071 144/528 (27%)
UDPGT 31..497 CDD:278624 137/497 (28%)
UGT1A6NP_001063.2 egt 15..506 CDD:223071 144/529 (27%)
UDPGT 27..523 CDD:278624 143/534 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165150733
Domainoid 1 1.000 260 1.000 Domainoid score I1978
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 267 1.000 Inparanoid score I3041
Isobase 1 0.950 - 0.698165 Normalized mean entropy S5056
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000004
OrthoInspector 1 1.000 - - mtm8543
orthoMCL 1 0.900 - - OOG6_100052
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X13
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.740

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