Protein Alignment Ugt49B2 and UGT1A7

DIOPT Version :9

• Sequence 1: NP_001097859.4
• Gene: Ugt49B2 / 42538
• FlyBaseID: FBgn0038886
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_061950.2
• Gene: UGT1A7 / 54577
• HGNCID: 12539
• Length: 530
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 155/539 - (28%)
• Similarity: 268/539 - (49%)
• Gaps: 49/539 - (9%)

  Fly     8 LFVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFITP---------LSLAKEN 62
            |:||||.|...|:......:|:. ||:....:::.:|:.|||||..:.|         |:...:.
Human    12 LYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKT 76

  Fly    63 LGPNY------REILLPKYDTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDFALAHPE 121
            ...:|      ||.::     :||.......:||..::..|.         .||    |.|....
Human    77 YSTSYTLEDQDREFMV-----FADARWTAPLRSAFSLLTSSS---------NGI----FDLFFSN 123

  Fly   122 VQELIYAKD-----KKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPL 181
            .:.|...:.     |:..||.:.::.|...|.::..| :.:|::..|...:.:|..:......||
Human   124 CRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKY-FSLPSVVFARGIFCHYLEEGAQCPAPL 187

  Fly   182 SYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQN 246
            ||||.:.|..:|.|:..||:.|.::...|.:     :.|.....:.:..|.:|....|...|..:
Human   188 SYVPRLLLGFSDAMTFKERVWNHIMHLEEHL-----FCPYFFKNVLEIASEILQTPVTAYDLYSH 247

  Fly   247 ISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLD-NAEHGAIYFSLGSQVRSAD 310
            .|:.||.:...|..|:|:..|||.:||::....||:|...:.|:: :.|||.:.|||||.|  ::
Human   248 TSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIVVFSLGSMV--SE 310

  Fly   311 MPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGM 375
            :|.:|.....|....:.|.|||::...:..||.:|..:.|||||.|:|.||..:.||.|.|..|:
Human   311 IPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGV 375

  Fly   376 QEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKA 440
            .|::.:.||::.||.:.||..|.|..:..|..:.|:...::.:.|::||.|::.|..|:.|:|:.
Human   376 YESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRL 440

  Fly   441 SRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITL-LPLLTLY 504
            |.:.:|||:..:|.|::|:.:|:.|:|||||..|...|.|||::.|||...:||:.| :..:|..
Human   441 SSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFK 505

  Fly   505 AVSRNYKSFRGIRAQKKEA 523
            ..:..|:...|.:.:.|:|
Human   506 CCAYGYRKCLGKKGRVKKA 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	150/516 (29%)
		UDPGT	31..497	CDD:278624	141/486 (29%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	146/520 (28%)
		egt	<264..504	CDD:223071	87/241 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150700
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790