Protein Alignment Ugt49B2 and UGT1A8

DIOPT Version :10

• Sequence 1: NP_001097859.4
• Gene: Ugt49B2 / 42538
• FlyBaseID: FBgn0038886
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_061949.3
• Gene: UGT1A8 / 54576
• HGNCID: 12540
• Length: 530
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 154/545 - (28%)
• Similarity: 268/545 - (49%)
• Gaps: 56/545 - (10%)

  Fly     3 LFMKLLFVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPN 66
            |.:.||..|  |..:..::|.   :|:. ||:....:::.:|:.|||||..:.|
Human    12 LCVSLLLTC--GFAEAGKLLV---VPMDGSHWFTMQSVVEKLILRGHEVVVVMP----------- 60

  Fly    67 YREILLPKYDTW---ADISAMMKTKSA-----------LDMIDMSKLTHMRLAQHIGIKSTD--F 115
              |:      :|   ..::..:||.|.           :|..|......:|....:.:.|::  |
Human    61 --EV------SWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFF 117

  Fly   116 ALAHPEVQELIYAKD-----KKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVF 175
            .|.....:.|...:.     |:..||.:.::.|...|.::..| :.:|::..|.....:|..:..
Human   118 NLFFSHCRSLFNDRKLVEYLKESSFDAVFLDPFDACGLIVAKY-FSLPSVVFARGIACHYLEEGA 181

  Fly   176 GFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTV 240
            ....||||||.:.|..:|.|:..||:.|.::...|.:.  ..|:.:....|.   |.:|....|.
Human   182 QCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLF--CQYFSKNALEIA---SEILQTPVTA 241

  Fly   241 KQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLD-NAEHGAIYFSLGS 304
            ..|..:.|:.||.:...|..|:|:..|||.:||::....||||...:.|:: :.|||.:.|||||
Human   242 YDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGS 306

  Fly   305 QVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAH 369
            .|  :::|.:|.....|....:.|.|||::...:..||.:|..:.|||||.|:|.||..:.||.|
Human   307 MV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITH 369

  Fly   370 GGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQ 434
            .|..|:.|::.:.||::.||.:.||..|.|..:..|..:.|:...::.:.|::||.|::.|..|:
Human   370 AGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYK 434

  Fly   435 ANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITL-L 498
            .|:|:.|.:.:|||:..:|.|::|:.:|:.|:|||||..|...|.|||::.|||...:||:.| :
Human   435 ENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTV 499

  Fly   499 PLLTLYAVSRNYKSFRGIRAQKKEA 523
            ..:|....:..|:...|.:.:.|:|
Human   500 AFITFKCCAYGYRKCLGKKGRVKKA 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	Glycosyltransferase_GTB-type	31..497	CDD:471961	141/487 (29%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	147/524 (28%)