DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and UGT1A8

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_061949.3	Gene:	UGT1A8 / 54576	HGNCID:	12540	Length:	530	Species:	Homo sapiens

Alignment Length:	545	Identity:	154/545 - (28%)
Similarity:	268/545 - (49%)	Gaps:	56/545 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LFMKLLFVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPN 66
            |.:.||..|  |..:..::|.   :|:. ||:....:::.:|:.|||||..:.|
Human    12 LCVSLLLTC--GFAEAGKLLV---VPMDGSHWFTMQSVVEKLILRGHEVVVVMP----------- 60

  Fly    67 YREILLPKYDTW---ADISAMMKTKSA-----------LDMIDMSKLTHMRLAQHIGIKSTD--F 115
              |:      :|   ..::..:||.|.           :|..|......:|....:.:.|::  |
Human    61 --EV------SWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFF 117

  Fly   116 ALAHPEVQELIYAKD-----KKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVF 175
            .|.....:.|...:.     |:..||.:.::.|...|.::..| :.:|::..|.....:|..:..
Human   118 NLFFSHCRSLFNDRKLVEYLKESSFDAVFLDPFDACGLIVAKY-FSLPSVVFARGIACHYLEEGA 181

  Fly   176 GFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTV 240
            ....||||||.:.|..:|.|:..||:.|.::...|.:.  ..|:.:....|.   |.:|....|.
Human   182 QCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLF--CQYFSKNALEIA---SEILQTPVTA 241

  Fly   241 KQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLD-NAEHGAIYFSLGS 304
            ..|..:.|:.||.:...|..|:|:..|||.:||::....||||...:.|:: :.|||.:.|||||
Human   242 YDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGS 306

  Fly   305 QVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAH 369
            .|  :::|.:|.....|....:.|.|||::...:..||.:|..:.|||||.|:|.||..:.||.|
Human   307 MV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITH 369

  Fly   370 GGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQ 434
            .|..|:.|::.:.||::.||.:.||..|.|..:..|..:.|:...::.:.|::||.|::.|..|:
Human   370 AGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYK 434

  Fly   435 ANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITL-L 498
            .|:|:.|.:.:|||:..:|.|::|:.:|:.|:|||||..|...|.|||::.|||...:||:.| :
Human   435 ENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTV 499

  Fly   499 PLLTLYAVSRNYKSFRGIRAQKKEA 523
            ..:|....:..|:...|.:.:.|:|
Human   500 AFITFKCCAYGYRKCLGKKGRVKKA 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	149/522 (29%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	141/487 (29%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	147/524 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150694
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790