DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and UGT1A10

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_061948.1	Gene:	UGT1A10 / 54575	HGNCID:	12531	Length:	530	Species:	Homo sapiens

Alignment Length:	550	Identity:	154/550 - (28%)
Similarity:	273/550 - (49%)	Gaps:	71/550 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFVCLL---GTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFITP---------LSLA 59
            |.||||   |..:..::|.   :|:. ||:....:::.:|:.|||||..:.|         |:..
Human    12 LCVCLLLTCGFAEAGKLLV---VPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLERSLNCT 73

  Fly    60 KENLGPNY------REILLPKYDTW-----ADISAMMKTKSA-LDMIDMSKLTHMR-------LA 105
            .:....:|      ||.::..:..|     :..|.:|.:.|. ||:.    .:|.|       |.
Human    74 VKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLF----FSHCRSLFNDRKLV 134

  Fly   106 QHIGIKSTDFALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANY 170
            :::                      |:..||.:.::.|...|.::..| :.:|::......:.::
Human   135 EYL----------------------KESSFDAVFLDPFDTCGLIVAKY-FSLPSVVFTRGIFCHH 176

  Fly   171 FSQVFGFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLP 235
            ..:......|||||||..|..:|.|:..||:.|.::...:.:..:   |..::|:  :..|.:|.
Human   177 LEEGAQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQ---YLFRNAL--EIASEILQ 236

  Fly   236 RVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLD-NAEHGAIY 299
            ...|...|..:.|:.||.:...|..|:|:..|||.:||::....||||...:.|:: :.|||.:.
Human   237 TPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVV 301

  Fly   300 FSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVK 364
            |||||.|  :::|.:|.....|....:.|.|||::...:..||.:|..:.|||||.|:|.||..:
Human   302 FSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTR 364

  Fly   365 VFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLK 429
            .||.|.|..|:.|::.:.||::.||.:.||..|.|..:..|..:.|:...::.:.|::||.|::.
Human   365 AFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVIN 429

  Fly   430 DPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILA 494
            |..|:.|:|:.|.:.:|||:..:|.|::|:.:|:.|:|||||..|...|.|||::.|||...:||
Human   430 DKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLA 494

  Fly   495 ITL-LPLLTLYAVSRNYKSFRGIRAQKKEA 523
            :.| :..:|....:..|:...|.:.:.|:|
Human   495 VVLTVAFITFKCCAYGYRKCLGKKGRVKKA 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	149/527 (28%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	140/494 (28%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	146/531 (27%)
UGT1A10	NP_061948.1	egt	<258..504	CDD:223071	90/247 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150697
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790