Protein Alignment Ugt49B2 and UGT2B28

DIOPT Version :9

• Sequence 1: NP_001097859.4
• Gene: Ugt49B2 / 42538
• FlyBaseID: FBgn0038886
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_444267.1
• Gene: UGT2B28 / 54490
• HGNCID: 13479
• Length: 529
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 157/562 - (27%)
• Similarity: 271/562 - (48%)
• Gaps: 98/562 - (17%)

  Fly    11 CLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFIT--------------------P 55
            |...:|...::|.  :....||:|....|::|||:||||||.:.                    |
Human    16 CYFSSGSCGKVLV--WTGEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYP 78

  Fly    56 LSLAKENLGPNYREILLPKYDTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDFALAHP 120
            .||.|    ..:..|::.:...|:|                             |:...|.|...
Human    79 TSLTK----TEFENIIMQQVKRWSD-----------------------------IQKDSFWLYFS 110

  Fly   121 EVQELI---------YAKD-----------KKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATF 165
            :.||::         :.||           ::.:||::..:.|...|.| |..:..||      |
Human   111 QEQEILWEFHDIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGEL-LAALLNIP------F 168

  Fly   166 AYANYFSQVF-------GFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQD 223
            .|:..|:..:       |.:.|.||:|.|....:|:|:..||::|::.....|...::....:.|
Human   169 VYSLCFTPGYTIERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDMKKWD 233

  Fly   224 AVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKN 288
                :.:|.:|.|..|:.:......:.|:.:......|.|...|:..|||||..|.||||:.::.
Human   234 ----QFYSEVLGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEE 294

  Fly   289 YLDNA-EHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWL 352
            ::.:: |:|.:.|||||.:  ::|.||:..:.....|.:.|:|||:|:.::...|..|.::.||:
Human   295 FVQSSGENGVVVFSLGSVI--SNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWI 357

  Fly   353 PQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISK 417
            ||.|:|..|..:.||.|||..|:.||:||.:|::|:|.::||..||...:|.|.|:.||:.|:|.
Human   358 PQNDLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTMSS 422

  Fly   418 DQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQ 482
            ..|.:||..::.||.|:.|:||.|.|..|:|:..:..|::||.:|:.|:||.||..|...|.|:|
Human   423 TDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAARDLTWFQ 487

  Fly   483 FYLLDVSAIILA--ITLLPLLTLYAVSRNYKSFRGIRAQKKE 522
            ::.|||...:||  .|::.::|.:.:...:|..|..:..|::
Human   488 YHSLDVIGFLLACVATVIFVVTKFCLFCFWKFARKGKKGKRD 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	153/540 (28%)
		UDPGT	31..497	CDD:278624	149/515 (29%)
UGT2B28	NP_444267.1	UDPGT	24..525	CDD:278624	154/548 (28%)
		egt	<269..506	CDD:223071	93/238 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150714
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790