DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt302E1

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_652625.2	Gene:	Ugt302E1 / 53508	FlyBaseID:	FBgn0040257	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	169/515 - (32%)
Similarity:	280/515 - (54%)	Gaps:	36/515 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLFVCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGP--NYRE 69
            ||.:.|.|...|...|.......|||:.:..|:.:.|...|||||.::|....|    |  |..:
  Fly    10 LLILALFGQSWGYSYLMISHTASKSHYAVCFALAKGLAAAGHEVTLVSPFPQRK----PIKNIID 70

  Fly    70 ILLPKYDTWADISAMMKTKSALDMIDMSK----LTHMRLAQHIGIKSTDFALAHPEVQELIYAKD 130
            :..|...|   :..:.|.:    :::.:|    |.:.|::. :|:..|:..|..|:||||:
  Fly    71 VETPNIIT---VMGVYKAR----ILENAKKPVLLRYPRISL-MGLDITESLLKEPKVQELL---- 123

  Fly   131 KKGK-FDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPLSYVPNVFLSCTDR 194
            |:.: ||.::.|.|.|:........:..|.||:::.....:.|.:.|..:|.||||:..|...||
  Fly   124 KQNRTFDGVICETFMNDAHYGFAEHFGAPLITLSSLGATGWTSDLVGTPSPPSYVPHSLLRFGDR 188

  Fly   195 MSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQ----LEQNISVILLNSY 255
            |:.|||.:|:.....|.....:...|:.:|:.||:|       |..||    :.::.|::|||::
  Fly   189 MNFWERAQNLGFQIYEFAYENLINLPRHEALYRKYF-------PNNKQDFYRMRKDTSLVLLNNH 246

  Fly   256 MPLTSPRPMSQNMISVGGLHI--LPPKPLPEHIKNYLDNAEHGAIYFSLGSQVRSADMPAEKLQI 318
            :.:::|||.|.|||.|||:|:  ..|||||::|:.:::.||||.|||||||.:.|.|:|..|.:.
  Fly   247 VSISNPRPYSPNMIEVGGMHVNRKAPKPLPQNIRKFIEEAEHGVIYFSLGSNLNSKDLPENKRKA 311

  Fly   319 FLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAV 383
            .::....||.||:||:|::...:.||||.:..||||.|||||..|..||.||||....|::||..
  Fly   312 IVETLRGLKYRVIWKYEEETFVDKPDNVLISNWLPQDDILAHEKVIAFITHGGLLSTMESIYHGK 376

  Fly   384 PVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRP 448
            ||:|:||:.||.:|:...:..||.|.:.|..::....:||:..:..||.:...:...|..:||:.
  Fly   377 PVVGIPFFGDQFMNMARAEQMGYGITVKYAQLTASLFRSAIERITSDPSFTERVKVISSQYRDQK 441

  Fly   449 LGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITLLPLLTLYAVSR 508
            ...::.|:||:.:|..|:||.:|.:|...|.:.|::.|||.|...::..|.::.::.:.|
  Fly   442 ETPLERAVYWVEHVTRHKGAKYLRSACQDLNFIQYHNLDVLATFFSVIGLTVIFVFLLVR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	168/507 (33%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	160/478 (33%)
Ugt302E1	NP_652625.2	egt	<114..464	CDD:223071	131/360 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454731
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	1	0.950	-	0.698165	Normalized mean entropy	S5056
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D58919at33392
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.850