DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and Ugt35E2

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	171/540 - (31%)
Similarity:	300/540 - (55%)	Gaps:	52/540 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MILFMKLLFVCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGP 65
            ::|.:.||.|.|    :|||||..|.:|..||:......:::|...|||:|.::|..| ||.:.
  Fly    11 IVLVVALLPVLL----EGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPL-KEPVA- 69

  Fly    66 NYREILLPK-YD--------------TWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDF 115
            |..:|.:|: :|              ||.:...:  .:..|.:::       ::.::.|::.
  Fly    70 NIHDIPVPELFDNIEEIVGNLTNRKGTWNEFEYI--NQYTLGLVE-------KVLENDGVRR--- 122

  Fly   116 ALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNP 180
            .:..||..:          |||::|:.:..:....|...::.|.|.||::.......::.|.|:|
  Fly   123 EILQPESLQ----------FDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSP 177

  Fly   181 LSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQ 245
            |:|:.:...:..|..:...||.:.|..:...:.....:..:.:||.||:|..:..: .::.::.:
  Fly   178 LAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPKIADK-RSLSEITR 241

  Fly   246 NISVILLNSYMPLTSPRPMSQNMISVGGLHI-LPPKPLPEHIKNYLDNA-EHGAIYFSLGSQVRS 308
            |.::||:|.:..:..|||...|:|.|||:|: ..||.||:.:::::..| |||.||||||:.|||
  Fly   242 NFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRS 306

  Fly   309 ADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLF 373
            .::..::.:|.:|.||||.||:||||:.|:|.::|.||.:..|.||.|||||||||:||.||||.
  Fly   307 RNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQ 371

  Fly   374 GMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMM 438
            ...|.::..||:||:||::||..|::..:|.|..:.|:||.::.|:.|..:|.||.:..:.....
  Fly   372 STVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAK 436

  Fly   439 KASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDV-SAIILAI-TLLPLL 501
            :.:..:||:|:..:|||::|.:||:.|:||||:..||.:|.:..::.||| ...:||: .:|.::
  Fly   437 RTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIV 501

  Fly   502 TLYAVSRNYKSFRGIRAQKK 521
            .|.|:    |..|.|...||
  Fly   502 VLCAI----KLLRAILKSKK 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	164/519 (32%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	151/484 (31%)
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	153/482 (32%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	134/438 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454698
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890