DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt35E1

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	166/549 - (30%)
Similarity:	303/549 - (55%)	Gaps:	62/549 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MILFMKLLFVCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGP 65
            ::||...|:        ||||||.|.:|..||:......::.|...|||:|.::|  ...|....
  Fly    11 ILLFPGFLY--------GARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSP--FPSEEPVK 65

  Fly    66 NYREILLPK-YDTWADISAMMKT-KSALDMIDMSKLTHMRLAQHI----GIKSTDFALAHPEVQE 124
            |..:|.:|: .:::.::...|.| |:..:..|.:......:.:.:    |::           :|
  Fly    66 NIYDIYVPEVLNSFDELLKQMTTPKNTWEFFDATNEFVYNITKDVFNNDGVR-----------RE 119

  Fly   125 LIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPLSYV--PNV 187
            ::  :..|.:|||::|:.:..:....|...:|.|.|.:|.........::.|..:|:||:  |:.
  Fly   120 IL--RPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQSPSS 182

  Fly   188 FLSCTDRMSLWERLENVVISTAEDVVREVS---------YYPQQDAVIRKHFSSLLPRVPTVKQL 243
            :|...|  :...|:.:||         ||:         |..:.:|:.:|:|..:....| :.::
  Fly   183 YLYNLD--TFGGRVAHVV---------EVAISWFNWHWRYEQKHEALYKKYFPKIAETKP-LSEI 235

  Fly   244 EQNISVILLNSYMPLTSPRPMSQNMISVGGLHI-LPPKPLPEHIKNYLD-NAEHGAIYFSLGSQV 306
            .|:|:::|:|.:..|..|||...|:|.|||:|| ..||.|.:.:::::. :.|||.||||||:.|
  Fly   236 SQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNV 300

  Fly   307 RSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGG 371
            |:.:|..::.:|.::.|.||.|||||||||::|.::|.||.|.|||||.|:||||.||:||.|||
  Fly   301 RTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGG 365

  Fly   372 LFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQAN 436
            :....|::::..|:||:||::||..|:...:..|:.:.|:|..::.|:||:.:..||.:.:::..
  Fly   366 MQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVT 430

  Fly   437 MMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSA--------IIL 493
            ...|...:||:|:..::||::|.:||:.|:||||:..||..|.::..:.|||..        :|:
  Fly   431 ARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLDVLGTVLLVILLVII 495

  Fly   494 AITLLPLLTLYAVSRNYKSFRGIRAQKKE 522
            ||.|:.:.::..:|:|..:...::.|:|:
  Fly   496 AILLIIVFSVCKISKNISTRLVVKKQRKQ 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	162/527 (31%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	150/492 (30%)
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	148/484 (31%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	147/477 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454701
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890