DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt303A1

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	158/509 - (31%)
Similarity:	260/509 - (51%)	Gaps:	27/509 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLFVCLLG-----TGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPN 66
            ||.|.|.|     ..:...|||.|.....|.:::....:|.||:|||::|.|:.:::.....|.:
  Fly    11 LLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPFLRNLVQRGHQLTLISAVTIMPHIEGVH 75

  Fly    67 YREILLPKYDTWADISAMMKTKSALDM---IDMSKLTHMRLAQHIGIKSTDFALAHPEVQELIYA 128
            :  |.:||.|        |..|..||.   .|::|.|..:.........:.|.|..|.||||:
  Fly    76 H--IRVPKLD--------MLMKILLDFEYDTDLTKWTEAQFLSEYFYNCSKFVLEDPGVQELL-- 128

  Fly   129 KDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPLSYVPNVFLSCTD 193
            ::...|:.|:::|..||:........:..|.:.:|.:..:.....:.|...|..|.|...|..|.
  Fly   129 RNASAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVGNSAPSVYEPMSALGYTS 193

  Fly   194 RMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPT-VKQLEQNISVILLNSYMP 257
            .::|.|:..|::..|.|.:|....|.|:|..:.::||    |...| :..|.:..|::|:|.:..
  Fly   194 GLNLIEKWHNLIYITEERLVERFIYLPRQIDLYKQHF----PGATTSIHDLRRRFSLVLINQHFT 254

  Fly   258 LTSPRPMSQNMISVGGLHI-LPPKPLPEHIKNYLDNAEHGAIYFSLGSQVRSADMPAEKLQIFLD 321
            :...|....|::.|.|:|: ..|.||...:|..||.||||.||||:|.|:....:|........|
  Fly   255 MGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILDEAEHGVIYFSMGLQLLDHWLPPGMRASMSD 319

  Fly   322 VFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVL 386
            .||.|||:|:||.:..::.|...||....|.||..||.|||||:||.|.||..:.|:|::|||:|
  Fly   320 AFAQLKQQVIWKTDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSLIESVHYAVPLL 384

  Fly   387 GMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGA 451
            .:|.::||..|.|..:..|.|..||::.:.:|::..|:..|:.:..|:.|....|:.|.|:|:.|
  Fly   385 CIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDLSQRFHDQPMSA 449

  Fly   452 MDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILA-ITLLPLLTLY 504
            ||||::|..|::.|:||.|:..|...:...|:|.:||.:::.. |.|..::.::
  Fly   450 MDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIF 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	158/505 (31%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	148/471 (31%)
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	143/454 (31%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	149/481 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454722
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890