DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and Ugt8

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_062149.1	Gene:	Ugt8 / 50555	RGDID:	3938	Length:	541	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	156/529 - (29%)
Similarity:	270/529 - (51%)	Gaps:	50/529 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLFVCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPNYREIL 71
            :|....:|....|:|:....:..:||..:...:...|.:|||...|:  ||..:: :.|: ....
  Rat     9 MLLWSAVGIARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVFL--LSEGRD-IDPS-NHYS 69

  Fly    72 LPKY-----DTWADISAMMKTK---------SALDMIDMSKLTHMRLAQHIGIKSTDFALAHPEV 122
            |.:|     .|.:|  |.:::|         :|::::|:  |.|.       .|:.|..:.:
  Rat    70 LQRYPGIFNSTTSD--AFLQSKMRNIFSGRLTAVELVDI--LDHY-------TKNCDMMVGN--- 120

  Fly   123 QELIYAKDKKGKFDLLLVEQFHNEGALMLGY-IYEIPAITIATFAYANYFSQVFGFVNPLSYVPN 186
            |.||... ||.|||||||:.  |:   |.|: |..:..:..|.|:...::....|...||:|||.
  Rat   121 QALIQGL-KKEKFDLLLVDP--ND---MCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPE 179

  Fly   187 VFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVIL 251
            .....||||:..||::|..:.....:.......|:.:.:::|:  :||| ..::..|....|:.:
  Rat   180 FNSLLTDRMNFLERMKNTGVYLISRMGVSFLVLPKYERIMQKY--NLLP-AKSMYDLVHGSSLWM 241

  Fly   252 LNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA-EHGAIYFSLGSQVR--SADMPA 313
            |.:.:.|..|||...|::.|||:...|..||||.::.::|.| |||.:..|.|:.|:  |.|: |
  Rat   242 LCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVDGAQEHGFVLVSFGAGVKYLSEDI-A 305

  Fly   314 EKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEA 378
            .||   ......|.|:|:|:|...:..||.:|.|:.:||||.|:|.|.|::.|::||||..:.|.
  Rat   306 NKL---AGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFET 367

  Fly   379 VYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRI 443
            :||.|||:|:|.:.|....:...||.|..|.|::.|:::.:|..||..::.:|.|:....|.|.|
  Rat   368 MYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEI 432

  Fly   444 FRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVS-AIILAITLLPLLTLYAVS 507
            .:|:|...::...|||:|::.|.||.||.:|...:.:.|::|||:: .::|....|..:..|...
  Rat   433 HKDQPGHPVNRTTYWIDYILRHDGAHHLRSAVHQISFCQYFLLDIAFVLLLGAVALYFIVSYVTK 497

  Fly   508 RNYKSFRGI 516
            ..|:..:.:
  Rat   498 FIYRKVKSL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	154/513 (30%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	149/484 (31%)
Ugt8	NP_062149.1	egt	8..490	CDD:223071	154/511 (30%)
Ugt8	NP_062149.1	UDPGT	21..502	CDD:278624	154/511 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344223
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.740