DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt303B1

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	157/529 - (29%)
Similarity:	268/529 - (50%)	Gaps:	38/529 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFVCLLGTGD---GARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPNYRE 69
            |.:|||...|   .|.||..|.....|.|.:...::|.|..|||.||.|||:.:..:..|  .|.
  Fly    10 LSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEG--VRH 72

  Fly    70 ILLPKYDTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDFALAHPEVQELIYAKDKKGK 134
            |.:.:.:  ..|..|:::...||.: ::|.|...|.......:::..|:.|.||.:::  ||...
  Fly    73 IRVAQLN--ERIKEMLESDQVLDFM-INKWTESALTAKALFNASNDILSDPGVQRMLH--DKSES 132

  Fly   135 FDLLLVE-----------QFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPLSYVPNVF 188
            |||:::|           :|:|  |.::|    :.:|.|....|     ::.|...|..|.|...
  Fly   133 FDLIIMEPSSLDALYGLVEFYN--ATLMG----LSSIRINWHTY-----ELAGNPAPSIYEPISP 186

  Fly   189 LSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLN 253
            :..:...||:.|:.|.:....|.:|..:...|.|..:.:|.|.....:   :.:|....|::|:|
  Fly   187 VGFSLETSLFSRVYNWIHIMEEKLVNYLILRPAQLHLFQKFFGYSAQK---MNELRSRFSLMLIN 248

  Fly   254 SYMPLTSPRPMSQNMISVGGLHIL-PPKPLPEHIKNYLDNAEHGAIYFSLGSQVRSADMPAEKLQ 317
            |:..:...|..:.|:|.|||||:. ||:|..|.::.:||.|:||.||||:|:.:....:|....:
  Fly   249 SHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKADHGVIYFSMGNDILIKFLPENIQE 313

  Fly   318 IFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHA 382
            :.|..||:|.:.::||.|...:|:..|||.|.:..||..||.||||::||.:|||..:.|||...
  Fly   314 LLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPNVRLFITNGGLLSVIEAVDSG 378

  Fly   383 VPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDR 447
            ||:||:|.:|||..|::..|.:|.|..:|..:::||.|...:..:|.:..|.....:.|:.|:||
  Fly   379 VPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNSYYLKAKEISQFFKDR 443

  Fly   448 PLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLD-VSAIILAITLLPLLTLYAVSRNYK 511
            |:..:|||::|..|.:.:|....:......:|..::|.:| :.|..|...|:....::.|...:.
  Fly   444 PMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFGLVAASLIFLVYTLFL 508

  Fly   512 SFRGIRAQK 520
            .:| ||.::
  Fly   509 KYR-IRLRR 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	153/509 (30%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	143/478 (30%)
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	141/461 (31%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	143/490 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454713
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890