DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt37A3

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	159/541 - (29%)
Similarity:	265/541 - (48%)	Gaps:	43/541 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LFMKLLFVCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPNY 67
            |.:.:....::|:..||.||..|.....||.::..:..:.|.:.||.||.:|.|.....:.....
  Fly     9 LLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTVLKPVVNHKNITV 73

  Fly    68 REILLPKYDTWADISAMMKTKSALDMIDMSK--LTHMRLAQHIG--IKSTDFALAHPEVQELIYA 128
            .::.|.|    .:...|..|..|:...|.|.  |:.:|::..:.  |:.....|.:..|::|..
  Fly    74 IQVPLSK----EEAQQMSDTIGAMSKNDNSNMALSLLRMSDQMDFMIRKNAETLMNDRVRDLYL- 133

  Fly   129 KDKKGKFDLLLVEQFHNEGALMLGYIYEI--PAITIATFAYANYFSQVFGFVNPL--SY--VPNV 187
             ::..||||::...|.|:  ..||:..::  |.|.:||....:..:.:.|  |||  ||  :.|.
  Fly   134 -NRGNKFDLVISGYFMND--FQLGFARKVNAPVIVLATMPPNHLLNPLIG--NPLEVSYAGISNP 193

  Fly   188 FLSCTDRMSLWERLENVVISTAEDVVREVS------YYPQQDAVIRKHFSSLLPRVPTVKQLEQN 246
             ...:..::...||.:.:.|....|...:|      :|        |......|::|...::.:|
  Fly   194 -AEGSKAVTFQRRLSSYMQSLGFGVFSHLSERRNRNWY--------KEVYGNDPKMPEYSEMLKN 249

  Fly   247 ISVILLNSYMPLTSP-RPMSQNMISVGGLHIL-PPKPLPEHIKNYLDNAEHGAIYFSLGSQVRSA 309
            .|::..:|:.....| ||...:.|.:||:.|. .|.|||::|..:|.||..|||..||||.|:..
  Fly   250 TSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLGNATDGAILLSLGSNVQGK 314

  Fly   310 DMPAEKLQIFLDVFASLKQRVLWKFED-DQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLF 373
            .:..:.:....:|.:.||:||:||:|| :..|....|:...|||||.|||||||:|:||.|.|..
  Fly   315 HLNPDTVAKMFNVLSKLKERVIWKWEDQENTPGKSANILYSKWLPQDDILAHPNIKLFINHAGKG 379

  Fly   374 GMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMM 438
            |:.|:.||..|:|.:|.:.||..|..|...:|:.:.|...|:.:...:.|:..:|.:|:|...:.
  Fly   380 GITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVK 444

  Fly   439 KASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITLLPLLTL 503
            ..|.::||||:.|.::.:||..||:.|.||.||.:..||:.:.....:|:..:|..| |:.:|.|
  Fly   445 SFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVI-LVSVLVL 508

  Fly   504 --YAVSRNYKSFRGIRAQKKE 522
              :.|...|:.|  |...|||
  Fly   509 IKFLVQFIYRRF--ISKPKKE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	150/517 (29%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	142/484 (29%)
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	146/499 (29%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	149/510 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454752
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.990