DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt35B1

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	189/528 - (35%)
Similarity:	288/528 - (54%)	Gaps:	15/528 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MILFMKLLFVCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGP 65
            :.|.:..|.:.|..:...|||||.|..|..|.::.....::||..|||:||.:......|..:
  Fly     2 LALRIGFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVV-- 64

  Fly    66 NYREILLPKYDTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDFALAHPEVQELIYAKD 130
            |:|::.:|  |.:.:...::...|.    .|:............:..|...|.:.||.|.:....
  Fly    65 NFRDVFIP--DVFNNYKELINELSG----PMNLWQENNFINKFFVSVTRCVLTNKEVTETLLPPG 123

  Fly   131 KKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPLSYVPNVFLSCTDRM 195
             |..|||::||...::........:..|.|.|:||........:.|..:||||.|......||||
  Fly   124 -KDHFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGNESPLSYTPLATGGLTDRM 187

  Fly   196 SLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTS 260
            :..|||.|.|.:|...:.....:..:|:.:..|:|.....|| .:..|.:|.|::|||.:..|:.
  Fly   188 TFLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRV-QLTDLNRNFSLVLLNQHFSLSF 251

  Fly   261 PRPMSQNMISVGGLHIL-PPKPLPEHIKNYLD-NAEHGAIYFSLGSQVRSADMPAEKLQIFLDVF 323
            |||...|||.||||||. .|.|||:.::.::. :.|||.|||||||.|.|.|:||::..:.|..|
  Fly   252 PRPYVPNMIEVGGLHISHKPAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTF 316

  Fly   324 ASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGM 388
            |||.||||||||||:||..|.||.:.||.||.||||||.||:||.||||....|:::|..||||:
  Fly   317 ASLPQRVLWKFEDDKLPGKPSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGL 381

  Fly   389 PFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMD 453
            ||::||.:|::....||:.:|||:.|:::.:||..:..|||:|::.....:.|..:||:|:..:|
  Fly   382 PFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERYRDQPMSPLD 446

  Fly   454 TAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITLLPLLTLYAVSRNYKSFRGIRA 518
            ||::|..||:.|:||.|:..||..|.::.::.|||..::|...||.:..:..|......|..
  Fly   447 TAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAIIVGVLGKLTDFGN--- 508

  Fly   519 QKKEAKTE 526
            .||:.|::
  Fly   509 AKKKLKSK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	184/502 (37%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	172/467 (37%)
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	174/467 (37%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	154/421 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454707
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890