DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt1a3

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_958827.1	Gene:	Ugt1a3 / 396551	RGDID:	1549728	Length:	531	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	162/547 - (29%)
Similarity:	269/547 - (49%)	Gaps:	58/547 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLFVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGH-------EVT-------FIT-- 54
            ||.:|.|...:|.::|.   .|:: ||::....::|||..|||       |||       |.|
  Rat    14 LLLLCALPWAEGGKVLV---FPMEGSHWLSMRDVVRELHARGHQAVVLAPEVTVHIKEEDFFTLQ 75

  Fly    55 --PLSLAKENLGPNYREILLPK----YDTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKST 113
              |:...||    .||..||..    ::|...:..:::..:|::.:....:...|...|
  Rat    76 TYPVPYTKE----EYRHHLLGHLQNFFETEFSLKLVLQRMAAVNNVSTFYVRSCRGLLH------ 130

  Fly   114 DFALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFV 178
            :.||    :|.|     ....||::|.:.|...||::..|: .:||:............:.....
  Rat   131 NTAL----IQSL-----NSSSFDVVLTDPFFPCGAVLAMYL-RVPAVFFLQSMLCELEFEATNSP 185

  Fly   179 NPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQL 243
            ||.||:|.:....:|.||..:|::|::.......:..|:|     ..:.:..|.||.|..:|.::
  Rat   186 NPSSYIPRLLTLNSDHMSFLDRVKNMLYPVPWMYLCHVNY-----GSLARLASDLLQREVSVVEI 245

  Fly   244 EQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLD-NAEHGAIYFSLGSQVR 307
            .::.||.||........|||...||:.:||::....|||.:..:.|:: :.|||.:.|||||.|
  Rat   246 LRHASVWLLRKDFVFYYPRPFMPNMVFIGGINCANRKPLSQEFEAYVNASGEHGIVVFSLGSMV- 309

  Fly   308 SADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGL 372
             :::|.:|.....:....:.|.|||::...:..||..|..:.|||||.|:|.||..:.||.|.|.
  Rat   310 -SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGS 373

  Fly   373 FGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANM 437
            .|:.|.:.:.||::.||.:.||..|.|..:..|..:.|:...::.|.|::||..::.:..|:.|:
  Rat   374 HGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENI 438

  Fly   438 MKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITLLPLLT 502
            |:.|.:.:|||:..:|.|::|:.||:.|:|||||..|...|.|||::.|||...:|||.|..:..
  Rat   439 MRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFI 503

  Fly   503 LYAVSRNY---KSFRGIRAQKKEAKTE 526
            :|. |..|   |.|.|....||..|::
  Rat   504 VYK-SCAYGCRKCFGGKGRVKKSHKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	153/518 (30%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	145/488 (30%)
Ugt1a3	NP_958827.1	UDPGT	26..522	CDD:278624	154/526 (29%)
Ugt1a3	NP_958827.1	egt	<228..505	CDD:223071	97/278 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860