DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_958826.1	Gene:	Ugt1a2 / 396527	RGDID:	1549741	Length:	533	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	156/552 - (28%)
Similarity:	260/552 - (47%)	Gaps:	68/552 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLFVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFITP--------------- 55
            ||.:|.|...:|.::|.   .|:: ||::....::|||..|||:...:.|
  Rat    16 LLLLCALPWAEGGKVLV---FPMEGSHWLSMRDVVRELHARGHQAVVLAPEVTVHMKGEDFFTLQ 77

  Fly    56 ---LSLAKENLGPNYREIL-------LPKYDTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGI 110
               ....||..   .||||       .|::........|...|...|:                .
  Rat    78 TYAFPYTKEEY---QREILGNAKKGFEPQHFVKTFFETMASIKKFFDL----------------Y 123

  Fly   111 KSTDFALAHPE--VQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQ 173
            .::..||.|.:  :|:|     ....||::|.:.....|||:..|: :|||:............:
  Rat   124 ANSCAALLHNKTLIQQL-----NSSSFDVVLTDPVFPCGALLAKYL-QIPAVFFLRSVPCGIDYE 182

  Fly   174 VFGFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVP 238
            ......|.||:||:....:|.|:..:|::|::.......:..:|..|.:...     |.||.|..
  Rat   183 ATQCPKPSSYIPNLLTMLSDHMTFLQRVKNMLYPLTLKYICHLSITPYESLA-----SELLQREM 242

  Fly   239 TVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLD-NAEHGAIYFSL 302
            ::.::..:.||.|.........|||:..||:.:||::.:..|||.:..:.|:: :.|||.:.|||
  Rat   243 SLVEVLSHASVWLFRGDFVFDYPRPIMPNMVFIGGINCVIKKPLSQEFEAYVNASGEHGIVVFSL 307

  Fly   303 GSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFI 367
            ||.|  :::|.:|.....:....:.|.|||::...:..||..|..:.|||||.|:|.||..:.||
  Rat   308 GSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFI 370

  Fly   368 AHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPK 432
            .|.|..|:.|.:.:.||::.||.:.||..|.|..:..|..:.|:...::.|.|::||..::.:..
  Rat   371 THSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKS 435

  Fly   433 YQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITL 497
            |:.|:|:.|.:.:|||:..:|.|::|:.||:.|:|||||..|...|.|||::.|||...:|||.|
  Rat   436 YKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVL 500

  Fly   498 LPLLTLYAVSRNY---KSFRGIRAQKKEAKTE 526
            ..:..:|. |..|   |.|.|....||..|::
  Rat   501 TVVFIVYK-SCAYGCRKCFGGKGRVKKSHKSK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	147/523 (28%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	139/493 (28%)
Ugt1a2	NP_958826.1	UDPGT	28..524	CDD:278624	148/531 (28%)
Ugt1a2	NP_958826.1	egt	<261..507	CDD:223071	88/247 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860