Protein Alignment Ugt49B2 and Ugt1a6b

DIOPT Version :10

• Sequence 1: NP_001097859.4
• Gene: Ugt49B2 / 42538
• FlyBaseID: FBgn0038886
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_958812.3
• Gene: Ugt1a6b / 394435
• MGIID: 3580629
• Length: 531
• Species: Mus musculus
• Alignment Length: 567
• Identity: 147/567 - (25%)
• Similarity: 259/567 - (45%)
• Gaps: 101/567 - (17%)

  Fly     8 LFVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVT-------------------- 51
            ||:.|..:..|.::|.   :|.. ||::....|:..|.:|||::.
Mouse    16 LFLVLWASVLGDKLLV---VPQDGSHWLSMKEIVEHLSERGHDIVVLVPEVNLLLGESKYYRRKI 77

  Fly    52 FITPLSLAKEN-----------------LGP--NYREILLPKYDTWADISAMMKTKSALDMIDMS 97
            |..|.||.:..                 :||  .||..:|.....:::..:::|..:.|..:
Mouse    78 FSVPYSLEELQTRFRTFGRNQFVPGAPLMGPLREYRNSMLTLEMFFSNCQSLLKDSATLSFL--- 139

  Fly    98 KLTHMRLAQHIGIKSTDFALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITI 162
                                             ::.|||.|..:.....|.::..|: .:|::
Mouse   140 ---------------------------------RENKFDALFTDPAMPCGVILAEYL-NLPSV-- 168

  Fly   163 ATFAYANY---FSQVFG-FVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQD 223
              :.:..:   ...:.| ..:|:||||..:...:|.|:..:||.|.:::..|:.: ....|.:.:
Mouse   169 --YLFRGFPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIVNILENYL-YYCLYSKYE 230

  Fly   224 AVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKN 288
            .::    :.||.|..::..|.|| |:.||........|||:..|||.:||::......|.:..:.
Mouse   231 IIV----TDLLKRDVSLPSLHQN-SLWLLRYDFVFEYPRPIMPNMIFIGGINCKKKGKLTQEFEA 290

  Fly   289 YLD-NAEHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWL 352
            |:: :.|||.:.|||||.|  :::|.:|.....:....:.|.|||::...:..||..|..:.|||
Mouse   291 YVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWL 353

  Fly   353 PQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISK 417
            ||.|:|.||..:.||.|.|..|:.|.:.:.||::.||.:.||..|.|..:..|..:.|:...::.
Mouse   354 PQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTA 418

  Fly   418 DQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQ 482
            |.|::||..::.:..|:.|:|:.|.:.:|||:..:|.|::|:.||:.|:|||||..|...|.|||
Mouse   419 DDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQ 483

  Fly   483 FYLLDVSAIILAITLLPLLTLYAVSRNY---KSFRGIRAQKKEAKTE 526
            ::.|||...:|||.|..:..::.... |   |.|.|....||..|::
Mouse   484 YHSLDVIGFLLAIVLTVVFIVFKCCA-YGCRKCFGGKGRVKKSHKSK 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	Glycosyltransferase_GTB-type	31..497	CDD:471961	133/509 (26%)
Ugt1a6b	NP_958812.3	UDPGT	27..522	CDD:278624	140/547 (26%)