DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and Ugt49B1

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	336/523 - (64%)
Similarity:	413/523 - (78%)	Gaps:	0/523 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ILFMKLLFVCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPN 66
            |..:.|:.:..|..|.|:||||.||.|.|||||||:||||||||:|||||||||.|||||.||.|
  Fly     9 IFLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSN 73

  Fly    67 YREILLPKYDTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDFALAHPEVQELIYAKDK 131
            |:||::|:||.|.:|..|....:.|:|.|:.....:|:...:||.:|||||..||:|.:|..|:|
  Fly    74 YKEIVIPQYDFWPEIKEMTNKNTVLEMTDLPTFAFLRMVNVMGIHTTDFALEQPEIQAVINEKNK 138

  Fly   132 KGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPLSYVPNVFLSCTDRMS 196
            .||:||||.|||.|||||:||::|:||.|||:||..||:.||:||.|:|.||||:.::..||||:
  Fly   139 IGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPHAYMPYTDRMT 203

  Fly   197 LWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSP 261
            ||||:.||.:|.|||:|||.||||.||||::||||.||.||||:|:||:|||.|||||||||.|.
  Fly   204 LWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSYMPLASS 268

  Fly   262 RPMSQNMISVGGLHILPPKPLPEHIKNYLDNAEHGAIYFSLGSQVRSADMPAEKLQIFLDVFASL 326
            |||:.|||.||||||.|||.||||::.:||.|.||||||||||||||||:|.|||::||:||.||
  Fly   269 RPMAYNMIPVGGLHIQPPKALPEHLQKFLDGATHGAIYFSLGSQVRSADLPPEKLKVFLEVFGSL 333

  Fly   327 KQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFY 391
            ||||||||||:.|||||.||||:.||||.|||||||||||||||||||.|||||:.||:||||.|
  Fly   334 KQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVY 398

  Fly   392 FDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAM 456
            .||..||..|::|.||:|||||.::.::|:..|..|:::|||:.|:.|||||||||||||||||:
  Fly   399 CDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAI 463

  Fly   457 YWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITLLPLLTLYAVSRNYKSFRGIRAQKK 521
            ||||||:||||||||||||||||||||||||:..:.||:.|||::.|..:.|.....:....:||
  Fly   464 YWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVILLPIVVLILICRRSSKPKSTPTKKK 528

  Fly   522 EAK 524
            ..|
  Fly   529 TKK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	331/499 (66%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	315/465 (68%)
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	332/503 (66%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	319/476 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468791
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H135484
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	1	0.950	-	0.698165	Normalized mean entropy	S5056
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47873at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	12	11.850