DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt36D1

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	157/513 - (30%)
Similarity:	264/513 - (51%)	Gaps:	49/513 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLFVC--------LLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFIT------PLS 57
            |||:.        |:......::|..|..|..|||.....|::.|.:.||:|:.::      |::
  Fly     8 LLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFPDKHPVA 72

  Fly    58 LAKENLGPNYREILLPKYDTWADISAMMKTKSALDMIDMSKLT---HMR---LAQHIGIKSTDFA 116
                    :|::.         .::.|.|..:::|:....|.|   |.:   |....|.::.:..
  Fly    73 --------HYKDF---------PLTGMDKLTNSVDLKFFEKRTFYSHFQEFFLLYDWGKQTCNLT 120

  Fly   117 LAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPL 181
            |....:|:::   .:.|:||::::|||:.:..:.:.:..:.|.|.:::.....:..:..|  .||
  Fly   121 LRSEALQQIL---RRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWHYERMG--APL 180

  Fly   182 --SYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLE 244
              |::|.:|::.:..|:...||.|...:.|.:.:.::...|..||:::..|..   .||:|.:|.
  Fly   181 IPSHIPALFMAQSQHMNFGGRLANWFSTHALNWMYKLLSVPAADAMVQYKFGH---DVPSVGELV 242

  Fly   245 QNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNAEHGAIYFSLGSQVRSA 309
            :|.|:..:|.:..|:.|:....|:|.:||:||...||||..::..|||||.|.|..|.||.:|:.
  Fly   243 KNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILDNAEEGVILISWGSMIRAN 307

  Fly   310 DMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFG 374
            .:.|.|....:...|.|||:|:||:|::.|||.|.|:.:.|||||.|||.|||||||::||||.|
  Fly   308 SLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNVKVFMSHGGLMG 372

  Fly   375 MQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMK 439
            ..||.|..|||:..|.|.||.:|..|....|....|::..|.::.:..||...| |.|:......
  Fly   373 TSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKAL-DKKFHDAAKV 436

  Fly   440 ASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITL 497
            .|..|..||..|:.||::|:.:|....|||.|..:.|.:..:.:|.|||.| :||:.|
  Fly   437 VSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYA-VLALVL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	157/513 (31%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	149/479 (31%)
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	146/486 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454686
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890