DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt36F1

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	168/546 - (30%)
Similarity:	279/546 - (51%)	Gaps:	45/546 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MKLLFVCLLG------TGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENL 63
            ||||.:.||.      ..|.|.||..|..|.||||.....:...|.:|||.::..:...|.|
  Fly     1 MKLLPLALLAFLLRPKPNDAAHILGLFQHPGKSHFDFFRPMFLALAERGHNISMYSYFPLEK--- 62

  Fly    64 GP--NYREILLPKYDTWADISAMMKTKSALDMIDMS-KLTHMRLAQHIGIKSTDFALAHPEVQEL 125
             |  ||.:.:........||..:...:|....:.:. |:....:....|::|...||..|.:.:|
  Fly    63 -PVANYTDYVFQGMPLLTDIVDLSNFESEWKPLGLPFKVPTYFMLHDWGLRSCKVALNSPLITQL 126

  Fly   126 IYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFG--FVNPLSYVPNVF 188
            :.:..   ::|::|:|.|.|:....:.::...|.|.:::.|...:..:..|  |:||:  :|..|
  Fly   127 LKSPI---RYDVILLEHFSNDCMAAVAHLLNAPVIALSSCAIMPWHYKRMGSPFINPI--MPMNF 186

  Fly   189 LSCTDRMSLWERLENV----VISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISV 249
            |..||.|||.:||.|.    .::|..:::.:    |..||:|.:.|.   |.:|.:.::.:|.|:
  Fly   187 LPYTDEMSLIDRLNNFFHFHTVNTLYNMITQ----PATDALIAERFG---PGLPPINEIVKNTSL 244

  Fly   250 ILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNAEHGAIYFSLGSQVRSADMPAE 314
            :|:|.:..||.|||.:.|:|.||||.:.|.||||:|:.:.||.:.:|.||.|.||.|.|..:|:.
  Fly   245 MLINQHYALTGPRPYAPNVIEVGGLQVGPIKPLPQHLLDLLDRSPNGVIYISWGSMVNSNTLPSG 309

  Fly   315 KLQIFLDVFASLKQR---VLWK----FEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGL 372
            |........:.||:.   :.||    .||.|    |.|:....||||.|:|.||.::.||:||||
  Fly   310 KRSALFQSISQLKEYNFVMRWKSLESLEDKQ----PSNLYTFDWLPQRDLLCHPKIRAFISHGGL 370

  Fly   373 FGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANM 437
            .|..||::..||:|..|||.||.:|..|.:..|:.:.:|:|....:.:...|..:| |.|:...:
  Fly   371 LGTTEAIHCGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRGLRIIL-DKKFAERV 434

  Fly   438 MKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITLLPLLT 502
            .::|..||.||:..:..|.:||.:|:::.||||:.:...|:.|..:..:||....|.|..|.::.
  Fly   435 RRSSEAFRQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWLGILFLLIVA 499

  Fly   503 LYAVSRNYKS--FRGIRAQKKEAKTE 526
            |..:.:.:|:  .||..::..:.||:
  Fly   500 LRKLIKIFKTAFCRGKISRDTKTKTQ 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	162/518 (31%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	148/481 (31%)
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	153/488 (31%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	135/443 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454692
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890