DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_787040.2	Gene:	Ugt1a8 / 301595	RGDID:	708474	Length:	530	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	158/550 - (28%)
Similarity:	270/550 - (49%)	Gaps:	64/550 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFVCLL---GTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPNYR 68
            |.|||.   |.....|:|.   :|:. ||:.....|:.:|..|||||..:.|
  Rat    12 LCVCLFLASGFAQAGRLLV---VPMDGSHWFTMQMIVEKLSHRGHEVVVVIP------------- 60

  Fly    69 EILLPKYDTW---ADISAMMKTKS-ALDMIDMSKLTHMRLAQHIGIKSTD---FALAHPEVQ--- 123
            |:      :|   ..::..:||.| :..:.|::  .|.:...|...|:.:   |:|.....:
  Rat    61 EV------SWHMGKSLNFTVKTYSVSYTLEDLN--YHFKFFAHNQWKTQEVGMFSLLKHSGKGFF 117

  Fly   124 ELIYA------KDKK-------GKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVF 175
            ||:::      ||||       ..||.:.::.|...|.::..| :.:|::..:...:.:|..:..
  Rat   118 ELLFSHCRSLFKDKKLVEYLKQSSFDAVFLDPFDVCGLILAKY-FSLPSVVFSGGIFCHYLDEGA 181

  Fly   176 GFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTV 240
            ...:|.||||.:....||.|:..||:.|.:     ..::|.::.|.......:..|.:|....|:
  Rat   182 QCPSPPSYVPRILSKFTDTMTFKERVWNHL-----SYMKERAFCPYFFKTAVEIASEVLQTPVTM 241

  Fly   241 KQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLD-NAEHGAIYFSLGS 304
            :.|...:|:.:..:...|..|||:..||:.:||::....|||.:..:.|:: :.|||.:.|||||
  Rat   242 RDLFSPVSIWMFRTDFVLEFPRPVMPNMVYIGGINCHQGKPLSKEFEAYVNASGEHGIVVFSLGS 306

  Fly   305 QVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAH 369
            .|  :::|.:|.....:....:.|.|||::...:..||..|..:.|||||.|:|.||..:.||.|
  Rat   307 MV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITH 369

  Fly   370 GGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQ 434
            .|..|:.|.:.:.||::.||.:.||..|.|..:..|..:.|:...::.|.|::||..::.:..|:
  Rat   370 SGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYK 434

  Fly   435 ANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITLLP 499
            .|:|:.|.:.:|||:..:|.|::|:.||:.|:|||||..|...|.|||::.|||...:|||.|..
  Rat   435 ENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTV 499

  Fly   500 LLTLYAVSRNY---KSFRGIRAQKKEAKTE 526
            :..:|. |..|   |.|.|....||..|::
  Rat   500 VFIVYK-SCAYGCRKCFGGKGRVKKSHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	149/521 (29%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	140/489 (29%)
Ugt1a8	NP_787040.2	UDPGT	26..521	CDD:278624	150/527 (28%)
Ugt1a8	NP_787040.2	egt	<263..504	CDD:223071	87/242 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860