DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001129341.1	Gene:	Ugt2a3 / 289533	RGDID:	1308444	Length:	534	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	159/531 - (29%)
Similarity:	265/531 - (49%)	Gaps:	68/531 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLFVCLLGTGDGARILA-PFFLPVKSHFMMTDAIIRELVKRGHEVTF------------ITPLSL 58
            ||.:|..|.|..:::|. |..:   ||::....|:.||..||||||.            :|||..
  Rat    12 LLQLCWSGCGICSKVLVWPCDM---SHWLNLKTILEELAARGHEVTVLKYPSIIIDQSKLTPLQF 73

  Fly    59 AKENLGPNY---------REI------LLPKYDTWADISAMMKTKSALDMIDMSKLTHMRLAQHI 108
              ||:...|         .||      ::|....|         ::|..:.|.    .::|..:.
  Rat    74 --ENIPVLYETEVAENHLNEIVNLAVNVIPNLSLW---------EAARTLQDF----FLQLTGNF 123

  Fly   109 G--IKSTDFALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYF 171
            .  .:||.:       .:.:..|.:..|:|:::::.....|.| :..:.:||.:....|:.....
  Rat   124 EDLCRSTLY-------NQTLMNKLRDAKYDVMVLDPVIPCGEL-VAEVLQIPFVNTLRFSMGYSM 180

  Fly   172 SQVFGFVN-PLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQD-AVIRKHFSSLL 234
            .:..|.:. ||||||.|....||.|:..||::|:::|...:.     :..|.| |...:.:|..|
  Rat   181 EKYCGQLPVPLSYVPVVMGELTDHMTFTERVKNMMLSLFFEF-----WLQQYDFAFWDQFYSKTL 240

  Fly   235 PRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA-EHGAI 298
            .|..|..:......:.|:.:|..:..|||...|...|||||..|.||||:.::.::.:: |||.:
  Rat   241 GRPTTFCKTVGKAEIWLIRTYWDIEFPRPYLPNFEFVGGLHCKPAKPLPKELEEFVQSSGEHGVV 305

  Fly   299 YFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNV 363
            .|||||.::  ::..||..:.....|.:.|:|||::...:...|..|.::..|:||.|:|.||..
  Rat   306 VFSLGSMIK--NLTEEKANLIASALAQIPQKVLWRYSGKKPATLGPNTRILNWIPQNDLLGHPKT 368

  Fly   364 KVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALL 428
            :.||.|||..|:.||:||.||::|:|.:.||..||...:|.|.|:.:...|::...|.|||.|::
  Rat   369 RAFITHGGTNGIYEAIYHGVPMVGIPMFGDQPYNIAHMEAKGAAVKVAINTMTSADLLSALRAVI 433

  Fly   429 KDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIIL 493
            .:|.|:.|.|:.||:..|:|:..:|.|::||.:|:.|:||.||..|...|.|:|::.|||...:|
  Rat   434 NEPSYKENAMRLSRVHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLL 498

  Fly   494 --AITLLPLLT 502
              .:||..::|
  Rat   499 VCVVTLTFVIT 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	158/529 (30%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	149/499 (30%)
Ugt2a3	NP_001129341.1	UDPGT	25..519	CDD:278624	154/518 (30%)
Ugt2a3	NP_001129341.1	egt	<268..506	CDD:223071	92/239 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344034
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.790