DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt2b7

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_775445.2	Gene:	Ugt2b7 / 286989	RGDID:	708417	Length:	529	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	171/556 - (30%)
Similarity:	275/556 - (49%)	Gaps:	70/556 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ILFMKLLFVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGP 65
            :|.:::.| | ..:|:..::|.   .|:: ||:|....|:.|||:||||||.:.|.|..
  Rat     9 LLLLQISF-C-FRSGNCGKVLV---WPLEYSHWMNLKIILDELVQRGHEVTVLRPSSSV------ 62

  Fly    66 NYREILLPK------YDTWADISAMMKTKSALDMI-------------DMSKLTHMRLAQHIGIK 111
                .|.||      |:|:       .|.|..|.:             |:.|.|.:|....:...
  Rat    63 ----FLDPKKASGLVYETF-------PTTSNNDEVEKFFTQWVNTWTYDVPKYTCLRYYPSLNKM 116

  Fly   112 STDFA-----LAHPEV-QELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANY 170
            ...|:     |....| .:.:.||.|:.:||::|.:.....|.| :..|.::|      |.|:..
  Rat   117 FGQFSDLWLQLCREVVSNKHLMAKLKESQFDVVLSDAVGPCGEL-IAEILQLP------FVYSLR 174

  Fly   171 FSQVFGFVN-------PLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRK 228
            |...:|...       |.||||.:....:.:|:..||:||::.....|...|  .:|.:|  ...
  Rat   175 FGIGYGIEKYSAGQPFPPSYVPIILSGLSGQMTFMERVENMLCLLYFDFWFE--SFPAKD--WDP 235

  Fly   229 HFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA 293
            .||.:|.|..|:....:...:.|:.||..|..|||...|:..|||||..|.||||:.::::..::
  Rat   236 FFSEILGRPTTMVDTMKKAEIWLIRSYWDLEFPRPSLPNIEFVGGLHCQPAKPLPKEMEDFAQSS 300

  Fly   294 -EHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADI 357
             |||.:.|||||.:|  ::..|:........|.:.|:|.|:||..:...|..|.:|.||:||.|:
  Rat   301 GEHGVVVFSLGSMIR--NITQERANTIASALAQIPQKVFWRFEGKKPDTLGPNTRVFKWIPQNDL 363

  Fly   358 LAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKS 422
            |.||..|.|:.|||..|:.|:::|.:|::|:|.:.:|..|:....|.|.|:.||:.|:|...|.:
  Rat   364 LGHPKTKAFVTHGGANGIYESIHHGIPMVGIPLFAEQRDNVAHMVAKGAAVSLDFHTMSSSDLLN 428

  Fly   423 ALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLD 487
            ||.|::..|.|:..:|..|.|..|:||..:|.|::||.:|:.|:||.||.....:|.|||::.||
  Rat   429 ALKAVINKPSYKKKVMWLSAIHHDQPLKPLDRAVFWIEFVMRHKGAKHLRPLAHNLAWYQYHSLD 493

  Fly   488 VSAIILAITL-LPLLTLYAVSRNYKSFRGIRAQKKE 522
            |...:||..| :.||.:......|:.|..:...|::
  Rat   494 VIGFLLACVLAIVLLAVKCCLFLYRFFVKVAKNKRD 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	167/534 (31%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	159/498 (32%)
Ugt2b7	NP_775445.2	UDPGT	24..527	CDD:278624	166/535 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860