DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and F10D2.8

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001309630.1	Gene:	F10D2.8 / 266913	WormBaseID:	WBGene00017334	Length:	494	Species:	Caenorhabditis elegans

Alignment Length:	519	Identity:	116/519 - (22%)
Similarity:	194/519 - (37%)	Gaps:	93/519 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPNYREILLPKYDTWADISAMM 85
            :..|.|  ..||......|...|...||.|||.||..:.|      ||.:...|.
Worm    21 VFCPLF--GHSHTKFFATIADALTDAGHNVTFFTPTIVEK------YRNVSYTKL---------- 67

  Fly    86 KTKSALDMIDMSKLTHMRLAQHIGIKSTDFALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGA-- 148
             ||..:.|....||  |...:.  ::|.||:        ..:.:|          ..|:|.||
Worm    68 -TKDVVHMDAPKKL--MEYGEQ--MESADFS--------RFWTED----------SSFYNVGAAD 109

  Fly   149 -----LMLGYIYE-----------IPAITIATFAYANYFSQVFGFVNPLSYVPNVFLSCTDRMSL 197
                 :.|..:::           ||::::   .:..|.|:..|.....|.|.:|.....|::||
Worm   110 LYRCSIRLNGLFKSLMDYLNIKTFIPSLSL---THDVYLSKAIGEPVMPSVVSDVCSPFGDKLSL 171

  Fly   198 WERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPR 262
            .||..|.......|:|..   ||     :....|:....: .::.:|...|.:.|||...|..||
Worm   172 LERAFNAFAVPYIDIVLG---YP-----VHNTLSAPYTEI-DIRTIEPEASFLFLNSNPFLDFPR 227

  Fly   263 PMSQNMISVGGLHI----LPPKPLPEHIKNYLDNAEHGAIYFSLGSQVRSADMPAEKLQIFLDVF 323
            |.....:.:||:.:    |..:.|.....:.| |.....:..|.||...|.|||.|..::..:..
Worm   228 PTLTKTVEIGGITVDLNQLKSQQLDSKWSDIL-NLREKTMLVSFGSVFFSKDMPLENKKVIANSM 291

  Fly   324 ASLKQ-RVLWKFEDDQLPNLP---DNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVP 384
            ...|. ..:||:|.:.:.:..   .|:...||:||..:||:..:..|..|.||..:.|..|...|
Worm   292 TEFKNVTFIWKYEGNDIEDFARGIQNIHFVKWVPQTALLANRRLSAFFTHAGLGSINEVSYLGKP 356

  Fly   385 VLGMPFYFDQDINIK-------AGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASR 442
            .:..|.:.||..|.|       :.:.:.|.:|      :..::..|..|:|.|..|..|..|.:.
Worm   357 SILCPLFADQMRNAKMLVRHNGSIELSKYDLG------NSKKIIEAFQAILFDSSYAENAQKLAE 415

  Fly   443 IFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITLLPLLTLYAV 506
            ...::|:......:....:.......|.|......:.:.:::||||:.|.:.:....:..|..|
Worm   416 QLENQPIKPEKMMVKHAEFAARFGRLPSLDPYSRKMSFVEYFLLDVATICVLVLACVVFVLTRV 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	114/513 (22%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	112/498 (22%)
F10D2.8	NP_001309630.1	UDPGT	29..492	CDD:278624	114/509 (22%)
F10D2.8	NP_001309630.1	Glycosyltransferase_GTB_type	<215..461	CDD:299143	58/252 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161553
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740