DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_036815.1	Gene:	Ugt1a1 / 24861	RGDID:	3935	Length:	535	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	160/554 - (28%)
Similarity:	274/554 - (49%)	Gaps:	60/554 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ILFMKLLFVCLLG--TGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFIT--------- 54
            :|.:..|.:|:||  .....::|.   :|:. ||::....:|::|.::||||..|.
  Rat    11 LLLLPCLLLCVLGPSASHAGKLLV---IPIDGSHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKE 72

  Fly    55 ---------PLSLAKENLGPNYREILLPKYDTWADISAMMKT----KSALDMIDMSKLTHMRLAQ 106
                     |:....||:...:.|:....:|....:..::||    |....|: :|..:|:
  Rat    73 GSFYTMRKYPVPFQNENVTAAFVELGRSVFDQDPFLLRVVKTYNKVKRDSSML-LSGCSHL---- 132

  Fly   107 HIGIKSTDFALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYF 171
               :.:.:|           .|..::..||.||.:.|...|:::..|: .:||:........:..
  Rat   133 ---LHNAEF-----------MASLEQSHFDALLTDPFLPCGSIVAQYL-SLPAVYFLNALPCSLD 182

  Fly   172 SQVFGFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPR 236
            .:......||||||....|.||||:..:|::|::|:..|:.:..|.|.|.....     :.:|.:
  Rat   183 LEATQCPAPLSYVPKSLSSNTDRMNFLQRVKNMIIALTENFLCRVVYSPYGSLA-----TEILQK 242

  Fly   237 VPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLD-NAEHGAIYF 300
            ..|||.|....|:.|:.:......|||:..||:.:||::.|..|.|.:..:.|:: :.|||.:.|
  Rat   243 EVTVKDLLSPASIWLMRNDFVKDYPRPIMPNMVFIGGINCLQKKALSQEFEAYVNASGEHGIVVF 307

  Fly   301 SLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKV 365
            ||||.|  :::|.:|.....:....:.|.|||::...:..||..|..:.|||||.|:|.||..:.
  Rat   308 SLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARA 370

  Fly   366 FIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKD 430
            ||.|.|..|:.|.:.:.||::.||.:.||..|.|..:..|..:.|:...::.|.|::||..::.:
  Rat   371 FITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINN 435

  Fly   431 PKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAI 495
            ..|:.|:|:.|.:.:|||:..:|.|::|:.||:.|:|||||..|...|.|||::.|||...:|||
  Rat   436 KSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAI 500

  Fly   496 TLLPLLTLYAVSRNY---KSFRGIRAQKKEAKTE 526
            .|..:..:|. |..|   |.|.|....||..|::
  Rat   501 VLTVVFIVYK-SCAYGCRKCFGGKGRVKKSHKSK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	151/525 (29%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	143/488 (29%)
Ugt1a1	NP_036815.1	UDPGT	30..526	CDD:278624	152/526 (29%)
Ugt1a1	NP_036815.1	egt	<263..509	CDD:223071	88/247 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860