DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt3a2

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_659094.1	Gene:	Ugt3a2 / 223337	MGIID:	2145969	Length:	523	Species:	Mus musculus

Alignment Length:	547	Identity:	156/547 - (28%)
Similarity:	265/547 - (48%)	Gaps:	57/547 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LFMKLLF--VCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGP 65
            |.|..||  |.||   :.|:||....|.. ||:::...:.:.|.:.||.|   |.|.....|: |
Mouse     8 LLMSFLFLEVILL---EAAKILTISTLSA-SHYIVISRVSQVLHEGGHNV---TKLLYESANI-P 64

  Fly    66 NYREILLPKYD--TWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDF-------ALAHPE 121
            ::|: ..|.|.  .|.......|..:.|......::|:.|...|..:|...:       .|:..:
Mouse    65 DFRK-EKPSYQVINWRPPEDQEKKFADLRHRLTEEITYGRSKHHTLLKIHQYFGDLCSQLLSRKD 128

  Fly   122 VQELIYAKDKKGKFDLLLVEQFHNEGALM---LG--YIYEIPAITIATFAYANYFSQVFGFVN-P 180
            :.:.:    |...|||:|::.......|:   ||  ::..:|    ..|:|.:     ||..: |
Mouse   129 IMDFL----KNENFDLVLLDSMDLCSLLIVEKLGKRFVSFLP----FQFSYMD-----FGLPSAP 180

  Fly   181 LSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQ 245
            |||.|......||:|..|.|::|.:: ..:..:::.....|.|:.|::||  :....|.:..|..
Mouse   181 LSYAPVYGSGLTDQMDFWGRVKNFLM-FLDFSMKQREILSQYDSTIQEHF--VEGSQPVLSDLLL 242

  Fly   246 NISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDN-AEHGAIYFSLGSQVRSA 309
            ...:..:||...|...||:..|.:.||||...|.:|:|:.::|::.. .:.|.:..:|||.| |.
Mouse   243 KAELWFVNSDFALDFARPLFPNTVYVGGLLDKPVQPIPQDLENFISQFGDSGFVLVALGSIV-SM 306

  Fly   310 DMPAEKLQIFLDVFASLKQRVLWKFEDDQLP---NLPDNVKVEKWLPQADILAHPNVKVFIAHGG 371
            ....|.::.....||.|.|.|||..:....|   :|..|||:..||||.|:||||::::|:.|||
Mouse   307 IQSKEIIKEMNSAFAHLPQGVLWTCKTSHWPKDVSLAPNVKIMDWLPQTDLLAHPSIRLFVTHGG 371

  Fly   372 LFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQAN 436
            :..:.|||:|.||::|:||:|||..|:...:|....:.:..:|:..:.....:..:::|.:|::.
Mouse   372 MNSVMEAVHHGVPMVGIPFFFDQPENMVRVEAKNLGVSIQLQTLKAESFALTMKKIIEDKRYKSA 436

  Fly   437 MMKASRIFR-DRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITL--- 497
            .| ||:|.| ..||......:.||:::::..||.||.......||::.|:|||...:|.:.|
Mouse   437 AM-ASKIIRHSHPLTPAQRLLGWIDHILQTGGAAHLKPYAFQQPWHEQYMLDVFLFLLGLMLGTL 500

  Fly   498 -LPLLTLYAVSRNYKSFRGIRAQKKEA 523
             |.:..|.||:|    :..|..:.|||
Mouse   501 WLSVKVLVAVTR----YLSIATKVKEA 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	148/524 (28%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	135/485 (28%)
Ugt3a2	NP_659094.1	UDPGT	23..488	CDD:278624	136/488 (28%)
Ugt3a2	NP_659094.1	egt	<235..488	CDD:223071	82/254 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840793
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740