DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt2b5

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_033493.3	Gene:	Ugt2b5 / 22238	MGIID:	98900	Length:	530	Species:	Mus musculus

Alignment Length:	523	Identity:	158/523 - (30%)
Similarity:	262/523 - (50%)	Gaps:	72/523 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SHFMMTDAIIRELVKRGHEVTFIT--------------------PLSLAKENLGPNYREILLPKY 75
            ||:|....|:.|||:||||||.:.                    |.|::|:||    ....:...
Mouse    34 SHWMNIKIILDELVQRGHEVTVLRPSAYYVLDPKKSPGLKFETFPTSVSKDNL----ENFFIKFV 94

  Fly    76 DTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDFALAHPEVQELIYAKD-----KKGKF 135
            |.|           ..:|...:.|::..|.|::..:.:|:.|:  ..::::..|:     ::.||
Mouse    95 DVW-----------TYEMPRDTCLSYSPLLQNMIDEFSDYFLS--LCKDVVSNKELMTKLQESKF 146

  Fly   136 DLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVF-------GFVNPLSYVPNVFLSCTD 193
            |:||.:...:.|.| :..:.:||      |.|:..||..:       .|:.|.||||.:......
Mouse   147 DVLLSDPVASCGEL-IAELLQIP------FLYSIRFSPGYQIEKSSGRFLLPPSYVPVILSGLGG 204

  Fly   194 RMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPL 258
            :|:..||::|::.....|...::....:.|:    .:|..|.|..|:.:......:.|:.|...|
Mouse   205 QMTFIERIKNMICMLYFDFWFQMFNDKKWDS----FYSEYLGRPTTLVETMGQAEMWLIRSNWDL 265

  Fly   259 TSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA-EHGAIYFSLGSQVRSADMPAEKLQIFLDV 322
            ..|.|...|:..|||||..|.||||:.::.::.:: :||.:.|||||.|  ::|..||.......
Mouse   266 EFPHPTLPNVDYVGGLHCKPAKPLPKDMEEFVQSSGDHGVVVFSLGSMV--SNMTEEKANAIAWA 328

  Fly   323 FASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLG 387
            .|.:.|:|||||:......|..|.:|.|||||.|:|.||..|.|:.|||..|:.||:||.:|::|
Mouse   329 LAQIPQKVLWKFDGKTPATLGHNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMIG 393

  Fly   388 MPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAM 452
            :|.:.:|..||....|.|.|:.|:.||:||..:.:||..::::|.|:.|.|..|.|..|:|:..:
Mouse   394 IPLFGEQHDNIAHMVAKGAAVALNIRTMSKSDVLNALEEVIENPFYKKNAMWLSTIHHDQPMKPL 458

  Fly   453 DTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDV---------SAIILAITLLPLLTLYAVSR 508
            |.|::||.:|:.|:.|.||...|.:|.|||::.|||         :.|:|::..|..:..:.|.:
Mouse   459 DRAVFWIEFVMRHKRAKHLRPLGHNLTWYQYHSLDVIGFLLSCVATTIVLSVKCLLFIYRFFVKK 523

  Fly   509 NYK 511
            ..|
Mouse   524 ENK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	156/512 (30%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	155/507 (31%)
Ugt2b5	NP_033493.3	egt	8..489	CDD:223071	149/484 (31%)
Ugt2b5	NP_033493.3	UDPGT	24..527	CDD:278624	158/523 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840781
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.790