DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and ugt-56

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_506074.2	Gene:	ugt-56 / 188073	WormBaseID:	WBGene00011453	Length:	524	Species:	Caenorhabditis elegans

Alignment Length:	538	Identity:	117/538 - (21%)
Similarity:	212/538 - (39%)	Gaps:	66/538 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSL--AKENLGPNYREILL 72
            :|:.|:.....|.||..:  :||...|..|...|..|||:||.|..:..  ....|..:..||:
Worm    12 LCIYGSAFDILIYAPRMM--QSHVYFTARIANVLAARGHKVTVIDNVFRYDVDNELSSDIHEII- 73

  Fly    73 PKYDTWADISAMMKTKSALDMIDMSK------------LTHMRLAQ--HIGIKSTDFALAHPEVQ 123
             ..:...:::.::.|.|...::..||            |.|:...|  |:...||    ..|::|
Worm    74 -SVEPSPEVTKLLNTGSLPTILWNSKASPEEQRTIMEGLGHVHRLQCTHLIENST----LIPKLQ 133

  Fly   124 ELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPLSYVPNVF 188
            |:        |||..:.|.|.:.|..:|..|.....:.:::....:......|..:.|: .|::.
Worm   134 EI--------KFDFAIHEVFDSCGVGILEVIGVQKTVIVSSTGPMDVVPITLGISDTLN-TPSLL 189

  Fly   189 LSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLN 253
            ......:|.:|:..|:...:.     .::::..||::|...|...........::.:..:::..|
Worm   190 SDYGSYLSFFEKRRNLKFLSG-----MLNFHEMQDSMISPLFKKYYGLKKPTGEIMRQANLLFYN 249

  Fly   254 SYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNAEHGAIYFSLGSQVRSADMPAEKLQI 318
            .:......|...:....:||:.....|.|....:..|.: ....:..|.|:...|:.|| :.|:.
Worm   250 IHEGSDGMRMRGRRSFDIGGIAFKDQKNLTMEYQTLLSD-PRPKVLVSFGTAATSSHMP-QNLKN 312

  Fly   319 FLDVFASLKQR----VLWKFE-DDQL---PNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGM 375
            .|  ..::||.    .:||:| :|..   ..|..|:..:|:|||.|:||...:.:|:.|.|...:
Worm   313 SL--MTAMKQMNNVLFIWKYEMEDNFTKQEELTTNIIFKKFLPQTDLLASSKIDLFVTHCGQNSL 375

  Fly   376 QEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGL-------DYRTISKDQLKSALHALLKDPKY 433
            .||....|.||.:|.:.||..|.|    ..:..||       |..|.:| .:|:....|..:.|.
Worm   376 LEAFNSGVRVLAVPLFGDQHRNAK----LAFENGLIEILPKSDIETPAK-IVKAVKTGLEPNAKL 435

  Fly   434 QANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHL--VAAGVHLPWYQFYLLDVSAIILAIT 496
            ..|::..|.:.|:....|.:..:..|.........|:.  .....| |.....|:| |:|.|...
Worm   436 DQNIVLISSLLRNSKENAENLLISTIEATYSTEFPPNFSKFPKNYH-PNTLVRLID-SSIALVFM 498

  Fly   497 LLPLLTLYAVSRNYKSFR 514
            |...:.:....:||..|:
Worm   499 LFIFVFVNHFRKNYVGFK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	114/524 (22%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	108/498 (22%)
ugt-56	NP_506074.2	Glycosyltransferase_GTB_type	<216..>399	CDD:299143	45/186 (24%)
ugt-56	NP_506074.2	Glycosyltransferase_GTB_type	<353..453	CDD:299143	29/104 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161619
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740