DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt-59

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_501911.1	Gene:	ugt-59 / 187799	WormBaseID:	WBGene00011238	Length:	506	Species:	Caenorhabditis elegans

Alignment Length:	527	Identity:	135/527 - (25%)
Similarity:	235/527 - (44%)	Gaps:	62/527 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KLLFVC-LLGTGDGARILAPFFLPV--KSHFMMTDAIIRELVKRGHEVTFI-------------T 54
            |:|.|| ::.......||  |::|.  .||......:.:.|...||:||.:             |
Worm     7 KILLVCTIINEFYTLNIL--FYVPTLSHSHISFNTKLAQLLATSGHQVTVLLAQVDDALLIENAT 69

  Fly    55 PLSLAKENLG---PNYREILLPKYDTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDFA 116
            ..::.::.:|   .:.|::|......:.| |:.:..:....::.:|. |.:...|::       |
Worm    70 DFAVLRKKVGVPRGHLRQVLWSNPGPYED-SSPLNPRIFYKLLKVSG-TFVTACQNM-------A 125

  Fly   117 LAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPL 181
            ..|     |..:..::.|||:.||||:.:.|..:...|.....:.::..|.....::..|...|.
Worm   126 FDH-----LFLSSLQQQKFDVGLVEQYDSCGFGIFKSIGIENTVWLSATAIYRPQAEALGVHLPY 185

  Fly   182 SYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQN 246
            ||||.:|...:|:||.::::.|::|..|...|.:|.....|..:.  .|...|..:      .|.
Worm   186 SYVPELFAHFSDKMSFFQKVINILIGQATSFVLDVFVQGFQSRIF--GFEQGLGAI------SQE 242

  Fly   247 ISVILLNSYMPLTSPRPMSQNMISVGGLHI-LPPKPLPEHIKNYLDNAEHGAIYFSLGSQVRSAD 310
            .|.:|:||........|:|....::||:.: ...|.|..:.::..|:||:|.:..|.|...|:.|
Worm   243 TSSVLINSVPFFDYSMPVSHQFSNIGGITVDKRDKKLDPYWQSIADSAENGFVLVSFGGIARTVD 307

  Fly   311 MPAEKLQIFLDVFASLKQ-RVLWKFE--DDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGL 372
            |.....:||.|.||.... ..:.|:|  .:...::||||.:..|:||..::||.|.|..|.|||.
Worm   308 MTESMQRIFYDSFARFSHITFIVKYETSSNSTISVPDNVILTPWIPQLPLMAHKNYKTIITHGGW 372

  Fly   373 FGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANM 437
            ..:.|...|:.|::.||.:.|...|.|..::.|.|:.||...:|:.::..|::.:|.:|||..|.
Worm   373 SSILETTMHSKPMILMPLFADHAKNSKVAESKGVAVLLDKMRLSRRRVVHAIYTILTNPKYTQNC 437

  Fly   438 MKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHL----PWYQFYLLDVSAIILAITLL 498
            .|.||:|.|.|:...:.    |.:.:.....|...|...||    |       |.|.:.|...::
Worm   438 EKFSRMFSDTPIPHEEL----IEWRIRQAAKPSRKAFAKHLRPKEP-------DFSYLKLGFLII 491

  Fly   499 PLLTLYA 505
            |.:.|||
Worm   492 PAMILYA 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	132/522 (25%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	123/489 (25%)
ugt-59	NP_501911.1	UDPGT	33..490	CDD:278624	123/489 (25%)
ugt-59	NP_501911.1	Glycosyltransferase_GTB_type	<247..492	CDD:299143	74/255 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910