DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt-32

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_504060.2	Gene:	ugt-32 / 185911	WormBaseID:	WBGene00018543	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	536	Identity:	139/536 - (25%)
Similarity:	222/536 - (41%)	Gaps:	52/536 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ILFMKLLFVCLLGTGDGARIL--APFFLPVKSHFM--MTDAIIRELVKRGHEVTFITPL--SLAK 60
            :||..::...:....|..|:|  :|.:....::||  :.|.    |.:.||.|||.||:  ...|
Worm     3 LLFKLMILYSVFSNTDSLRVLVYSPAYAASHTNFMARLADT----LTEAGHNVTFFTPIIDESRK 63

  Fly    61 ENLGPNY-REILLPKYDTW-----ADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDFALAH 119
            :..|... :::|:.:.|..     ..|...||.....|:...:....|.......|.:.:....|
Worm    64 DQFGVKLTKDVLILEQDEQVKRNPVTIDNDMKYFWTTDVTSANGHKVMGTLHKQAIFTCENVFKH 128

  Fly   120 PE-VQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANY--FSQVFGFVNPL 181
            .| :.||     :...:|:.|.|.....|..:..:| .|..:.:.| :..||  .....|.....
Worm   129 QELIDEL-----RSRNYDIGLAEPLMTCGLALFRHI-GIEKVMLTT-SCTNYDILLPATGEPEDT 186

  Fly   182 SYVPNVFLSCTDRMSLWERLEN-----VVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVK 241
            ||.|::....||.||.|:||||     |:|.|.|.:      :..:..|.||:...   ..|..:
Worm   187 SYNPSMNSQVTDVMSFWQRLENYDLYHVMIPTFETI------FDDEANVYRKYLGE---SFPDWR 242

  Fly   242 QLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHI----LPPKPLPEHIKNYLDNAEHGAIYFSL 302
            .|..:.|:...||...|..|||..|..|.:||:.:    :|  |:.|...|.||......: .|.
Worm   243 DLIPDASLHFTNSIPFLDFPRPSIQKTIEIGGIAVDIESIP--PVNEEFSNILDKRPMNML-ISF 304

  Fly   303 GSQVRSADMPAEKLQIFLDVFASLKQ-RVLWKFEDDQL--PNLPDNVKVEKWLPQADILAHPNVK 364
            ||..||.:||....:..|.||.|... ..:||:|.|.:  .|..:||...||:||..||....:.
Worm   305 GSLARSTEMPIIFKENLLRVFQSEPNCTFIWKYESDDVAFANDVENVIFVKWMPQTAILKDNRLT 369

  Fly   365 VFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQ-LKSALHALL 428
            .|:.||||....||.:...|.:..|.:.||..|.........:|.|....:...| ::.|.|.:|
Worm   370 AFLTHGGLGSTNEAAFLGKPSVMFPIFADQSRNSNMLGRQEMSIVLHKSDLGNFQKIRDAFHEIL 434

  Fly   429 KDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAI-I 492
            .:.||..|..|.:.:.|::|....|..:..:.:|.......|:....:.:|:||.|..|:... .
Worm   435 HNEKYHLNARKVADMVRNQPAKPRDIFVKHVEFVGRFGPLHHMTPYSLKMPFYQRYHYDIFIFKF 499

  Fly   493 LAITLLPLLTLYAVSR 508
            |....:|::.|..|::
Worm   500 LTNYFIPVVFLLCVTK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	137/528 (26%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	130/492 (26%)
ugt-32	NP_504060.2	Glycosyltransferase_GTB_type	1..508	CDD:299143	137/527 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161634
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.790