DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt-38

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_504812.1	Gene:	ugt-38 / 184294	WormBaseID:	WBGene00017333	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	573	Identity:	145/573 - (25%)
Similarity:	227/573 - (39%)	Gaps:	98/573 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ILFMKLLFVCLLGTGD-GARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGP 65
            :|.:.|||........ ...:..|.|....|.|..|  |...|...||.|.|.||:.:.|
Worm     1 MLLLALLFTLYANVSSFNFLVFCPLFAHSHSKFFAT--IADSLTDAGHNVAFFTPIIVEK----- 58

  Fly    66 NYREILLPKYDTWADISAMMKTKSALDMIDM--SKLTHMRLAQHIGIKST-DFALAHPE---VQE 124
             ||..   .|           |||..|::.|  ||    :|.::....|| ||.....|   ..|
Worm    59 -YRNF---NY-----------TKSTKDVVYMEPSK----KLKEYGRQMSTGDFVRYWTEDSTATE 104

  Fly   125 LI---------------YAKD--------KKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFA 166
            :|               ..||        ||.|||:::.|.|......::.|: |||.. |.:.:
Worm   105 IITVVRIFQKMYNEQGTVMKDNIEILNDLKKRKFDVIIFEAFIFSAYPLMDYL-EIPTF-IPSLS 167

  Fly   167 YANYFSQVFGFVNPLSYVPNVFLSCT----DRMSLWERLENVVISTAEDVVREVSYYPQQDAVI- 226
            .|:..:.......|:  :|:|...|.    |::|:.||..|..:         |.|:   |.:|
Worm   168 VAHDTALAVEIGEPV--MPSVVSDCLSPFGDKLSITERAFNAFM---------VPYF---DFMIG 218

  Fly   227 -RKHFSSLLPRVP-TVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHI----LPPKPLPEH 285
             ..|.|...|..| .::.:....|.:.|||...:..|||.....|.:||:.:    |..:.|.|.
Worm   219 YPTHRSFKPPYNPIDIRSIVPEASFVFLNSNPFVDFPRPTLTKTIQIGGISVDSNELRSQKLDET 283

  Fly   286 IKNYLDNAEHGAIYFSLGSQVRSADMPAEK---LQIFLDVFASLKQRVLWKFEDDQLPNLP---D 344
            ....|...|. .:..|.||.:.|.|||.:.   |:..::.|.::  ..:||:|||......   :
Worm   284 WSEILKLREK-TMLVSFGSMLYSKDMPFKNKIALKNAMEKFKNV--TFIWKYEDDSSDEFAKGIE 345

  Fly   345 NVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIG 409
            |:...||:||..:||...:..|:.|.||..:.|..|...|.:..|..|||..|.|.......:|.
Worm   346 NIHFAKWVPQTALLADSRLSAFLTHAGLGSITELSYLGKPAILCPQLFDQMRNTKMLVRHNGSIE 410

  Fly   410 LDYRTISK-DQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVA 473
            |....:.| :::..|..|:|.|..|..|..|.:....::|:...:..:....|.......|.|..
Worm   411 LSKYDLGKSEKIIEAFQAILFDSSYAKNAQKLAEQLENQPIKPKEMMVKHAEYAARFGRLPSLDP 475

  Fly   474 AGVHLPWYQFYLLDVSAIILAITLLPLLTLYAVSRNYKSFRGIRAQKKEAKTE 526
            ....:.:.:::||||:||.:.|.   ...::.|::..:|...|...|:  |||
Worm   476 YSRKMSFVEYFLLDVAAICVFIL---TFVVFVVTKLVQSLFDIFLIKR--KTE 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	138/547 (25%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	132/512 (26%)
ugt-38	NP_504812.1	Glycosyltransferase_GTB_type	12..512	CDD:299143	135/547 (25%)
ugt-38	NP_504812.1	UDPGT	29..521	CDD:278624	136/541 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161607
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.740