DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt-40

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_504810.2	Gene:	ugt-40 / 184292	WormBaseID:	WBGene00017331	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	550	Identity:	133/550 - (24%)
Similarity:	228/550 - (41%)	Gaps:	61/550 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLFVCLLGTGDGARILAPFFLPV--KSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPNYRE 69
            |.::.|:.:.....||.  |.|:  .||......:...|.:.||.||..:|..:.:..   ||..
Worm     8 LYYLLLISSTTSYNILV--FCPLFGHSHSTFFGRLADILTEAGHNVTLFSPTIIDEFR---NYSY 67

  Fly    70 ILLPKYDTWADISAMMKTKSALDMIDMSK------LTHMRLAQHIGIKSTDFALAHPEVQELIYA 128
            ..|.|...:.|.|..:|...  |:|..:|      .:...:.|     :|.|..:....|..:.|
Worm    68 TKLTKDVAYLDPSPELKAIG--DLIAGNKRWWNQEFSVFEIPQ-----TTRFFKSITREQNNVLA 125

  Fly   129 KD-------KKGKFDLLLVEQFHNEGALMLGYIYEIPAITIA-TFAYANYFSQVFGFVNPLSYVP 185
            .:       |:.||||:|.|........::.|: ||.:..:| :.||........|.....|::|
Worm   126 NNLALLDGLKQKKFDLILFESVFTCALPLMEYL-EIKSFAVAQSIAYEPITLGALGDTVMTSHIP 189

  Fly   186 NVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVI 250
            |:....:|:|||.||:.|.:|....:|......|.|.       :::...::.|:::|.: .|.|
Worm   190 NLMAQSSDKMSLCERMLNTLIQAMLNVYGMTPEYYQS-------YTNPEKKIYTLEKLSE-ASFI 246

  Fly   251 LLNSYMPLTSPRPMSQNMISVGGLHI-----LPPKPLPEHIKNYLDNAEHGAIYFSLGSQVRSAD 310
            .:||...|..||......|.:||:.:     .....|.|.....| |.....:..|.||.:.|.|
Worm   247 FMNSNPFLDFPRATITKNIQIGGISVNLDTLKSSGKLTEEWDQIL-NLREKTLLVSFGSVILSQD 310

  Fly   311 MP-AEKLQIFLDVFASLKQ----RVLWKFEDD---QLPNLPDNVKVEKWLPQADILAHPNVKVFI 367
            || |.|    :.:..::||    ..:||:|.|   :..|...|:...||:||.::||.|.:..|:
Worm   311 MPFAYK----VGLTNAMKQLNDVTFIWKYEGDDKKEFANGIKNIHFSKWVPQRELLADPRLSAFM 371

  Fly   368 AHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLD-YRTISKDQLKSALHALLKDP 431
            .||||..:.|..|...|.:..|...||..|.|..:....:|... |...::..:.:|...:|.|.
Worm   372 THGGLGSVNEVSYFGKPTIMCPLSGDQMRNAKMLERHNGSIEFSKYDLHNEKVVANAFRKILYDE 436

  Fly   432 KYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAIT 496
            .|..:..:.|...:.:|:...:..:..:.:.......|.|......:.:.|::|:|::.|:|.:.
Worm   437 SYTLSAKRLSEHLQFQPVKPKELFLKHVEFAARFGKLPSLDPYSRQMGFIQYFLIDIAFIVLTVV 501

  Fly   497 LLPLLTLYAVSRNYKSFRGIRAQKKEAKTE 526
            |..:..||.|.:...|     ..|.:.||:
Worm   502 LTIVSVLYFVLKFVAS-----CLKAKIKTD 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	126/524 (24%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	119/493 (24%)
ugt-40	NP_504810.2	YjiC	22..447	CDD:224732	114/450 (25%)
ugt-40	NP_504810.2	Glycosyltransferase_GTB_type	<247..503	CDD:299143	64/260 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161556
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740