DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt-43

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001255487.1	Gene:	ugt-43 / 184052	WormBaseID:	WBGene00008485	Length:	540	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	123/548 - (22%)
Similarity:	225/548 - (41%)	Gaps:	76/548 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GARILAPFFLPVKSH----FMMTDAIIRELVKRGHEVTFITPL---SLAKENLGPNYREILLPKY 75
            |.::|.  :|||..|    ||.|.:.|  |.:.|:.||.:.||   :|...|: |..::|   |:
Worm    26 GKKVLV--YLPVTGHSHLKFMSTTSNI--LQEEGYNVTLLLPLIDITLNNTNI-PIVKKI---KH 82

  Fly    76 DTWADI-SAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDF-ALAH----------------PEV 122
            ....|| ..:|:|     :|.|..:...|....:|.....| .::|                |.:
Worm    83 RINLDIHPGVMRT-----IIKMGGMASRRQTWTMGSGIYGFDGISHLLSDLYSNICDNIFHMPGL 142

  Fly   123 QELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPLSYVPNV 187
            .:.:.|:    |:::.:.|.|...|..:..::.....|::.:...........||....||:|..
Worm   143 LDRLKAE----KYEMGMSEPFFVCGFALFDHLGIDKIISVDSHIGLEGPKIAHGFPVTSSYLPAA 203

  Fly   188 FLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILL 252
            |...:|.||..||..::..:........:.:..:.||:     ..:.....|.::|.:..:.:..
Worm   204 FSESSDHMSFVERTRSLYETYLNRKFARLIHNKEIDAM-----KGVYKGKSTWEELMRLPAYMFT 263

  Fly   253 NSYMPLTSPRPMSQNMISVGGLHILPPK---PLPEHIKNYLDNAEHGAIYFSLGSQVRSADMP-- 312
            ||...|..|.|.....|.:||:.....|   .|||...:.| |..:..:..|.||..:|..||
Worm   264 NSNPILDFPYPRPSKFIEIGGIAADEKKHDEVLPESYDHIL-NLRNRTVLISFGSNAKSIFMPDH 327

  Fly   313 -AEKLQIFLDVFASLKQRVLWKFEDDQL-------PNLPDNVKVEKWLPQADILAHPNVKVFIAH 369
             ...|.|.|.:...:  ..:||:|:..:       |.:.:.|:|: |:||..:||.|.:.:|:.|
Worm   328 MRRSLIIALGMMPDI--TFIWKYENSSIDIVKEFDPTIKNIVQVD-WMPQQALLADPRLDLFVTH 389

  Fly   370 GGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAI-----GLDYRTISKDQLKSALHALLK 429
            ||:....|..:...|.:.:|.:.||..|.:..:..|..:     .|:|..|..:.:.|    :|.
Worm   390 GGMASTNEIAFSGKPAVMVPVFGDQTRNSRMLERHGGVLMLRKENLEYPEIVIETILS----VLN 450

  Fly   430 DPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILA 494
            ||.|.....:.:.:.|:.|.......:.:.|:|........:.:..:::.:..:|.||:.|.:|
Worm   451 DPSYAERAQQLATLLRNHPESPKQVFLKYFNFVARFGKPTGIDSNSINVDFIAYYYLDLIAFLL- 514

  Fly   495 ITLLPLLTLYAVSRNYKSFRGIRAQKKE 522
              ::.....:.||..|..|..:|.:|.|
Worm   515 --IVAYFAKFLVSHVYSYFCYLRKEKAE 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	116/526 (22%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	111/508 (22%)
ugt-43	NP_001255487.1	Glycosyltransferase_GTB_type	<215..517	CDD:299143	69/317 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860