DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt-15

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_506211.1	Gene:	ugt-15 / 183462	WormBaseID:	WBGene00008097	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	563	Identity:	135/563 - (23%)
Similarity:	228/563 - (40%)	Gaps:	79/563 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLFVCLLGTGDGARILA--PFFLPVKSHFM--MTDAIIRELVKRGHEVTFITPLSLAKENLGPNY 67
            ||.:.||......::|.  |.|....|:|:  ::|.    |:..||:||.:.|:.:..:.
Worm     6 LLTLLLLELVCSYKVLVFNPAFGASHSNFLGKISDI----LIDAGHDVTMLIPVCMESKK----- 61

  Fly    68 REILLPKYDTWADISAMMKTKS--ALDMIDMSKL------THMRLAQHIGIKSTD---------- 114
                        |:....|.|.  .:|....|||      |...:.:.|.....|
Worm    62 ------------DLVGSKKVKKIIRIDQEPRSKLMQEEAKTEEMIKKQIWKLDADITIFFSMIKN 114

  Fly   115 FALAHPEVQELIYAKD------KKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQ 173
            |::|.....|.|:.:.      :...|||.:.|.....|..:|..|.....|...:..|.:....
Worm   115 FSIASGYQCENIFKQTAILEQLRNEHFDLGITESLFICGFPLLDSIGVKTIINADSVLYLDVVKH 179

  Fly   174 VFGFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVP 238
            ..|.....||.|.|:....||||..||:.|:.............:..:.:| |:.:::..|
Worm   180 ALGEPASTSYYPGVYAKNIDRMSFRERVRNLFGMAFSWYFSWTRFQGELEA-IKPYYNKSL---- 239

  Fly   239 TVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLD-------NAEHG 296
            |.:......:...:||...|..|.|.....:.:||:.:...|    |.|..|:       |....
Worm   240 TWEDHINGAAYYFINSNQYLDYPSPTLPKTVFIGGMQVNTNK----HGKVKLEKEWDDLLNLRKQ 300

  Fly   297 AIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRV-LWKFED------DQLPNLPDNVKVEKWLPQ 354
            .:..|.||...|.|||.|..:.||.||||:.:.. :||:|.      |||    .|||:..|:||
Worm   301 NVLVSFGSNAFSCDMPDEFKESFLKVFASMPETTFIWKYEQENATLADQL----SNVKLTTWMPQ 361

  Fly   355 ADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTI-SKD 418
            .||||...:.:|:.||||....|..|...|.:.:|...||..|.......|.|:.||...: :.:
Worm   362 NDILADERLTLFVTHGGLGSSMELAYQGKPAVVIPLMADQPRNALMLTRHGGALQLDKTFLNNSE 426

  Fly   419 QLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQF 483
            :::.|:..::::|.|:.|..|.:.|...:|....|..:...::.|:|.....|.:.|.||..:|:
Worm   427 KIREAIQTVMENPSYKKNAEKLANILSSQPHQPKDVVLKHCDFAVKHGDLKTLNSEGRHLNVFQY 491

  Fly   484 YLLDV--SAIILAITLLPLLTLYAVSRNYKSFRGIRAQKKEAK 524
            |.:|:  :|.:..:|::..:....:....|.:...|:.|::.:
Worm   492 YSIDIALAAGLFLVTIISFIIFTIIFVFKKVYFMCRSDKQKVE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	132/539 (24%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	124/508 (24%)
ugt-15	NP_506211.1	UDPGT	19..506	CDD:278624	127/520 (24%)
ugt-15	NP_506211.1	Glycosyltransferase_GTB_type	<252..493	CDD:299143	73/248 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161610
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.790