DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt-50

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_741913.1	Gene:	ugt-50 / 181413	WormBaseID:	WBGene00011564	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	140/571 - (24%)
Similarity:	255/571 - (44%)	Gaps:	105/571 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MKLLFVCLLGTGDG------ARILAPFFLP--VKSHFMMTDAIIRELVKRGHE-VTFITPLSLAK 60
            |:.:|.||.....|      |:||.  :.|  .|||.::.......|...||: |.||
Worm     6 MRWMFFCLTALLHGSFIVNAAKILV--YCPSISKSHVLLCSKYADLLHNAGHDTVLFI------- 61

  Fly    61 ENLGPNYREILLPKYD------TWA--DISAMMKTKSALDMIDMSKLTHMRLAQHIGI------- 110
                |:|.: ||..||      .|.  :::....||       :..|.::....|||.
Worm    62 ----PSYSK-LLDNYDGAKHAKVWRLHNVTEAYDTK-------LGTLANVMENSHIGFIDRLTFD 114

  Fly   111 ------KSTDFALAHPEVQELI-YAKDKKGKFDLLLVEQFHNE-----GALMLGYIYEIP-AITI 162
                  ...|.....||:|.:| |      ||||::    :||     .|::  .::.|| .:.:
Worm   115 ADFWIDMCADLLGKLPEMQHIIDY------KFDLVI----YNEIDPCTPAIV--RLFNIPKTVLL 167

  Fly   163 ATFAYANYFSQVFGFVNPLSYVPNVFLSCT-DRMSLWERLENVVISTAEDVVREVSYYPQQDAVI 226
            ::.|..:..:...|.....||||:|..:.. ||||.:||:.||.......||    :|.|...|:
Worm   168 SSEAIMDKVAWNLGLPTLPSYVPSVEENPNHDRMSFFERMSNVYKFFQSIVV----HYLQDIHVL 228

  Fly   227 ---RKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPK--PLPEHI 286
               ||..||   ..|::.::.:|:|::|:|:......||..|...:.||.|.....:  .||:..
Worm   229 NLFRKEVSS---DFPSIAEIIRNVSLVLVNTDEIFDLPRSYSSKFVYVGMLEAGKDENVTLPKKQ 290

  Fly   287 KNYLDNAEHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKF-----EDD----QLPNL 342
            .:|....:.|:::.|.|:......:| |::|  |.:..::::...:.|     .||    |..:.
Worm   291 DDYFKKGKSGSVFVSFGTVTPFRSLP-ERIQ--LSILNAIQKLPDYHFVVKTTADDESSAQFFST 352

  Fly   343 PDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYA 407
            ..||.:..|:||..:|.|.|:|:|::|||:..:.|.:|:.||::.||.:.||..|.:..:..|..
Worm   353 VQNVDLVDWVPQKAVLRHANLKLFVSHGGMNSVLETMYYGVPMVIMPVFTDQFRNGRNVERRGAG 417

  Fly   408 IGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLV 472
            ..:...|:.|:....|:|::|::..|.:::.:.|.:.:::|..:.:....||::|:::..:.|..
Worm   418 KMVLRETVVKETFFDAIHSVLEEKSYSSSVKRISHLMKNKPFTSEERVTKWIDFVLKYETSEHFD 482

  Fly   473 AAGVHLPWYQFYLLDVSAIILAITLLPLLTLYAVSRNYKSFRGIRAQKKEA 523
            ....:|...:...||:...:..|:||          |:..:|.|..:|.::
Worm   483 LESNNLSIIEHNHLDLFFYLCIISLL----------NFVVYRKIFKRKSQS 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	136/548 (25%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	124/509 (24%)
ugt-50	NP_741913.1	egt	9..475	CDD:223071	128/508 (25%)
ugt-50	NP_741913.1	UDPGT	26..520	CDD:278624	134/546 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810